Institute of Cardiovascular Regeneration Webtool Repository

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info
Description:	Casitas B-lineage lymphoma b
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSMUSG00000022637	Cblb	10090	+	16:52031549-52208047	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENSMUST00000114471		Cblb-201	52031549-52208047	protein_coding

Expression Patterns

Transcript ID	Adipose	Adrenal	Bladder	Brain	Breast	Colon	Heart	Kidney	Liver	Lung	Muscle	Ovary	Placenta	Testis
ENSMUST00000114471	3.965±0.49	2.230±1.19	2.787±0.36	12.577±0.75	5.520±1.34	1.771±0.33	2.030±0.76	1.759±0.57	1.279±0.69	6.140±0.63	1.208±0.28	3.953±1.39	2.686±1.54	4.976±2.44

Conserved Regions
Region ID	Sub-Region	Region Type	Position
CIL_0003IY	CIL_0003IY_0002	CGP	16:52031549-52454074

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0001784	IEA	phosphotyrosine binding
GO:0002669	IMP	positive regulation of T cell anergy
GO:0004842	IEA	ubiquitin-protein transferase activity
GO:0004871	IEA	signal transducer activity
GO:0005509	IEA	calcium ion binding
GO:0005515	IPI	protein binding
GO:0005737	IEA	cytoplasm
GO:0006955	IMP	immune response
GO:0007166	IEA	cell surface receptor signaling pathway
GO:0008270	IEA	zinc ion binding
GO:0016567	IEA	protein ubiquitination
GO:0035556	IMP	intracellular signal transduction
GO:0042110	IMP	T cell activation
GO:0045732	IMP	positive regulation of protein catabolic process
GO:0046642	IMP	negative regulation of alpha-beta T cell proliferation
GO:0050860	IMP	negative regulation of T cell receptor signaling pathway

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000015199	cblb	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	protein_coding	Danio_rerio
ENSG00000114423	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	protein_coding	Homo_sapiens

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