C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Cbl proto-oncogene B, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000114423 CBLB 9606 - 3:105655461-105869552 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264122 CBLB-001 105655461-105869043 protein_coding
  ENST00000394030 CBLB-007 105655461-105702201 protein_coding
  ENST00000403724 CBLB-002 105680992-105869043 protein_coding
  ENST00000405772 CBLB-003 105680992-105869043 protein_coding
  ENST00000407712 CBLB-005 105658405-105682130 protein_coding
  ENST00000438603 CBLB-009 105853414-105869422 protein_coding
  ENST00000443752 CBLB-008 105853414-105869552 protein_coding
  ENST00000447441 CBLB-010 105853414-105869422 protein_coding
  ENST00000476370 CBLB-006 105658269-105673993 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264122ENST00000394030ENST00000405772ENST00000407712ENST00000438603ENST00000447441ENST00000476370
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264122 4.148±0.00 2.128±0.00 0.689±0.00 0.469±0.05 1.673±0.45 3.669±0.00 2.762±1.76 1.237±0.56 1.411±0.81 2.066±0.25 0.638±0.50 1.445±0.45 1.646±0.42 2.639±0.00
ENST00000394030 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.749±0.00 N/A N/A
ENST00000405772 3.864±0.00 N/A N/A N/A 4.007±0.00 3.075±0.00 3.125±0.23 N/A 3.541±0.00 4.123±0.00 2.504±0.00 1.878±0.54 2.352±0.75 1.204±0.00
ENST00000407712 6.250±0.00 2.294±0.00 N/A N/A N/A 5.852±0.00 N/A N/A 0.929±0.00 7.761±0.00 1.755±0.81 3.498±0.91 4.568±1.21 3.832±0.39
ENST00000438603 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.659±0.00 N/A N/A N/A
ENST00000447441 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.490±0.00
ENST00000476370 1.167±0.00 0.938±0.00 0.535±0.00 0.155±0.00 N/A N/A 1.069±0.14 0.509±0.00 2.034±0.00 2.357±0.00 N/A 0.938±0.31 N/A 1.109±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001784 IEA phosphotyrosine binding
GO:0002669 IEA positive regulation of T cell anergy
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0004871 IEA signal transducer activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006607 TAS NLS-bearing protein import into nucleus
GO:0006955 IEA immune response
GO:0007165 TAS signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0008270 IEA zinc ion binding
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0023051 IEA regulation of signaling
GO:0035556 IEA intracellular signal transduction
GO:0042110 IEA T cell activation
GO:0045732 IEA positive regulation of protein catabolic process
GO:0046642 IEA negative regulation of alpha-beta T cell proliferation
GO:0046872 IEA metal ion binding
GO:0050860 IEA negative regulation of T cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015199 cblb Cas-Br-M (murine) ecotropic retroviral transforming sequence b protein_coding Danio_rerio
ENSMUSG00000022637 Cblb Casitas B-lineage lymphoma b protein_coding Mus_musculus

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