C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hematopoietic cell specific Lyn substrate 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022831 Hcls1 10090 + 16:36934983-36963212 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023531 Hcls1-001 36934983-36963212 protein_coding
  ENSMUST00000163755 Hcls1-003 36954751-36956633 retained_intron
  ENSMUST00000164050 Hcls1-002 36937287-36961530 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023531ENSMUST00000164050
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023531 7.230±1.64 3.996±1.90 6.429±0.37 1.076±0.56 14.400±6.11 2.152±0.72 2.843±0.73 3.588±1.58 8.376±5.83 11.028±1.16 1.144±1.03 4.955±2.29 8.150±4.40 0.304±0.11
ENSMUST00000164050 N/A N/A N/A 0.599±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0003779 IEA actin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0008284 IMP positive regulation of cell proliferation
GO:0009725 IDA response to hormone
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017124 IPI SH3 domain binding
GO:0019901 IEA protein kinase binding
GO:0030041 IEA actin filament polymerization
GO:0030218 IMP erythrocyte differentiation
GO:0030833 IEA regulation of actin filament polymerization
GO:0030854 IMP positive regulation of granulocyte differentiation
GO:0032403 IPI protein complex binding
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0042531 IMP positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993 IEA positive regulation of transcription factor import into nucleus
GO:0045651 IMP positive regulation of macrophage differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0071345 IEA cellular response to cytokine stimulus
GO:2000107 IEA negative regulation of leukocyte apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012729 hcls1 hematopoietic cell-specific Lyn substrate 1 protein_coding Danio_rerio
ENSG00000180353 HCLS1 hematopoietic cell-specific Lyn substrate 1 protein_coding Homo_sapiens

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