C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hematopoietic cell-specific Lyn substrate 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180353 HCLS1 9606 - 3:121631399-121660927 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000314583 HCLS1-001 121631399-121660911 protein_coding
  ENST00000428394 HCLS1-004 121631715-121660898 protein_coding
  ENST00000464274 HCLS1-014 121637146-121660883 nonsense_mediated_decay
  ENST00000468693 HCLS1-013 121656059-121660878 processed_transcript
  ENST00000473883 HCLS1-006 121631400-121644183 processed_transcript
  ENST00000479994 HCLS1-008 121657982-121660903 retained_intron
  ENST00000481314 HCLS1-011 121644230-121660901 retained_intron
  ENST00000487290 HCLS1-003 121644121-121660898 processed_transcript
  ENST00000488033 HCLS1-009 121653565-121660916 processed_transcript
  ENST00000491824 HCLS1-007 121656891-121660919 retained_intron
  ENST00000495491 HCLS1-002 121632406-121660927 nonsense_mediated_decay
  ENST00000497391 HCLS1-010 121644818-121660919 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000314583ENST00000428394ENST00000464274ENST00000473883ENST00000481314ENST00000495491ENST00000497391
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000314583 47.917±0.00 76.723±0.00 0.608±0.00 5.527±4.67 10.405±6.83 4.784±3.53 10.772±0.00 12.715±8.28 9.527±6.77 14.204±9.56 1.601±0.00 23.077±19.75 61.039±7.98 2.590±1.39
ENST00000428394 N/A N/A 0.626±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000464274 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.153±0.00 N/A N/A N/A N/A
ENST00000473883 N/A N/A N/A 0.102±0.00 N/A 1.348±0.00 0.117±0.00 N/A N/A 2.216±0.11 0.331±0.00 N/A N/A 0.284±0.00
ENST00000481314 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.082±0.00 N/A 2.173±0.00 N/A N/A
ENST00000495491 N/A N/A N/A 7.716±0.00 N/A 2.055±0.00 0.192±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000497391 N/A N/A N/A N/A N/A N/A 0.644±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00057R CIL_00057R_0002 CGP 3:121631399-121749767

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0003779 IEA actin binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0008284 ISS positive regulation of cell proliferation
GO:0009725 ISS response to hormone
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0017124 IEA SH3 domain binding
GO:0019901 IPI protein kinase binding
GO:0030041 IEA actin filament polymerization
GO:0030218 ISS erythrocyte differentiation
GO:0030833 IMP regulation of actin filament polymerization
GO:0030854 IMP positive regulation of granulocyte differentiation
GO:0032403 IEA protein complex binding
GO:0033138 IMP positive regulation of peptidyl-serine phosphorylation
GO:0035556 TAS intracellular signal transduction
GO:0042531 ISS positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993 IMP positive regulation of transcription factor import into nucleus
GO:0045651 IEA positive regulation of macrophage differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0071345 IMP cellular response to cytokine stimulus
GO:2000107 IMP negative regulation of leukocyte apoptotic process
GO:2000251 IC positive regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012729 hcls1 hematopoietic cell-specific Lyn substrate 1 protein_coding Danio_rerio
ENSMUSG00000022831 Hcls1 hematopoietic cell specific Lyn substrate 1 protein_coding Mus_musculus

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