C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sirtuin 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025138 Sirt7 10090 - 11:120618372-120625240 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000080202 Sirt7-001 120618372-120625014 protein_coding
  ENSMUST00000106183 Sirt7-002 120623990-120624984 protein_coding
  ENSMUST00000127882 Sirt7-006 120618372-120625240 retained_intron
  ENSMUST00000130743 Sirt7-009 120621990-120622802 retained_intron
  ENSMUST00000133625 Sirt7-011 120618374-120624999 retained_intron
  ENSMUST00000134255 Sirt7-005 120618388-120625020 retained_intron
  ENSMUST00000146809 Sirt7-003 120618420-120620977 protein_coding
  ENSMUST00000152331 Sirt7-010 120620999-120624990 processed_transcript
  ENSMUST00000153018 Sirt7-007 120623280-120624992 retained_intron
  ENSMUST00000153532 Sirt7-008 120618372-120624969 retained_intron
  ENSMUST00000154714 Sirt7-004 120618769-120619369 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000080202ENSMUST00000127882ENSMUST00000133625
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000080202 19.889±0.36 23.632±0.00 21.618±3.27 N/A 16.855±1.97 25.101±3.08 7.964±0.00 25.857±2.13 23.369±3.24 27.701±2.51 25.225±4.12 19.806±0.00 5.725±1.01
ENSMUST00000127882 N/A 16.451±1.83 N/A 8.458±0.00 8.368±0.92 11.795±1.08 N/A N/A N/A 8.908±0.00 13.577±3.29 N/A N/A
ENSMUST00000133625 N/A 20.297±0.40 15.192±2.74 N/A 14.065±1.57 12.280±2.00 N/A N/A N/A N/A 18.545±0.58 N/A 4.428±1.13

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004LV CIL_0004LV_0002 CGP 11:120610087-120625240
CIL_0004LW CIL_0004LW_0002 CGP 11:120618372-120633600

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0003682 ISS chromatin binding
GO:0005515 IEA protein binding
GO:0005730 ISS nucleolus
GO:0005731 ISS nucleolus organizer region
GO:0005737 IEA cytoplasm
GO:0007072 ISS positive regulation of transcription on exit from mitosis
GO:0009303 ISS rRNA transcription
GO:0046872 IEA metal ion binding
GO:0070403 IEA NAD+ binding
GO:0070932 ISS histone H3 deacetylation
GO:0070933 IEA histone H4 deacetylation
GO:0097372 ISS NAD-dependent histone deacetylase activity (H3-K18 specific)

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060645 sirt7 sirtuin 7 protein_coding Danio_rerio
ENSG00000187531 SIRT7 sirtuin 7 protein_coding Homo_sapiens

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