C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: a disintegrin and metallopeptidase domain 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025473 Adam8 10090 - 7:139978932-139992562 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026546 Adam8-002 139978932-139992548 protein_coding
  ENSMUST00000106069 Adam8-001 139978932-139992562 protein_coding
  ENSMUST00000128332 Adam8-004 139978932-139992562 retained_intron
  ENSMUST00000132903 Adam8-007 139979394-139980368 processed_transcript
  ENSMUST00000148670 Adam8-005 139983854-139992562 protein_coding
  ENSMUST00000149915 Adam8-006 139987654-139988430 processed_transcript
  ENSMUST00000156647 Adam8-003 139978932-139988434 retained_intron
  ENSMUST00000173209 Adam8-008 139989419-139992508 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000026546ENSMUST00000106069ENSMUST00000128332ENSMUST00000132903ENSMUST00000148670ENSMUST00000149915ENSMUST00000156647
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000026546 2.102±0.34 N/A 1.337±0.04 2.290±0.35 2.342±0.63 0.737±0.22 0.737±0.22 0.196±0.00 0.420±0.53 3.641±0.54 0.178±0.05 13.594±3.89 6.434±5.11
ENSMUST00000106069 1.237±0.17 0.491±0.00 N/A N/A 1.430±0.00 0.506±0.13 0.437±0.04 0.193±0.05 0.509±0.19 2.205±0.05 0.134±0.00 7.504±1.61 2.944±2.22
ENSMUST00000128332 N/A 0.603±0.10 N/A 0.491±0.04 1.261±0.34 N/A 0.054±0.00 0.102±0.01 0.240±0.20 1.553±0.00 0.103±0.04 N/A N/A
ENSMUST00000132903 N/A N/A N/A N/A N/A N/A N/A N/A 0.193±0.00 N/A N/A N/A N/A
ENSMUST00000148670 N/A N/A N/A N/A N/A N/A 0.110±0.00 0.207±0.05 N/A N/A 0.085±0.03 N/A 9.853±0.00
ENSMUST00000149915 N/A N/A N/A N/A N/A N/A N/A N/A 0.440±0.00 N/A N/A N/A N/A
ENSMUST00000156647 1.583±0.22 0.775±0.18 1.021±0.28 0.972±0.22 1.691±0.38 0.679±0.24 1.115±0.01 0.160±0.04 0.281±0.29 3.227±0.83 0.092±0.01 12.147±3.44 1.057±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000479 CIL_000479_0003 CGP 7:139978932-140036350

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 IMP cell morphogenesis
GO:0001525 IDA angiogenesis
GO:0002102 ISS podosome
GO:0002523 IMP leukocyte migration involved in inflammatory response
GO:0002675 IMP positive regulation of acute inflammatory response
GO:0002693 IMP positive regulation of cellular extravasation
GO:0004222 IEA metalloendopeptidase activity
GO:0005178 TAS integrin binding
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005737 ISS cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006508 IEA proteolysis
GO:0006954 IEA inflammatory response
GO:0007160 TAS cell-matrix adhesion
GO:0008237 IDA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0009986 IEA cell surface
GO:0016337 IDA single organismal cell-cell adhesion
GO:0022407 ISS regulation of cell-cell adhesion
GO:0032010 ISS phagolysosome
GO:0032127 ISS dense core granule membrane
GO:0033089 IDA positive regulation of T cell differentiation in thymus
GO:0035419 IDA activation of MAPK activity involved in innate immune response
GO:0042581 ISS specific granule
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043534 NAS blood vessel endothelial cell migration
GO:0045670 NAS regulation of osteoclast differentiation
GO:0045780 IDA positive regulation of bone resorption
GO:0045785 IDA positive regulation of cell adhesion
GO:0048247 IDA lymphocyte chemotaxis
GO:0048729 TAS tissue morphogenesis
GO:0050729 IDA positive regulation of inflammatory response
GO:0050839 IPI cell adhesion molecule binding
GO:0051044 IDA positive regulation of membrane protein ectodomain proteolysis
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0061025 TAS membrane fusion
GO:0070245 IMP positive regulation of thymocyte apoptotic process
GO:0070820 ISS tertiary granule
GO:0071065 ISS alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071133 IDA alpha9-beta1 integrin-ADAM8 complex
GO:0071456 ISS cellular response to hypoxia
GO:0072675 TAS osteoclast fusion
GO:2000309 IMP positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391 IEA positive regulation of neutrophil extravasation
GO:2000399 NAS negative regulation of thymocyte aggregation
GO:2000406 IMP positive regulation of T cell migration
GO:2000415 IMP positive regulation of fibronectin-dependent thymocyte migration
GO:2000418 IMP positive regulation of eosinophil migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001452 adam8a a disintegrin and metalloproteinase domain 8a protein_coding Danio_rerio
ENSDARG00000057644 adam8b a disintegrin and metalloproteinase domain 8b protein_coding Danio_rerio
ENSG00000151651 ADAM8 ADAM metallopeptidase domain 8 protein_coding Homo_sapiens

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