C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: synuclein, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025889 Snca 10090 - 6:60731573-60829855 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000114268 Snca-201 60731573-60828996 protein_coding
  ENSMUST00000163779 Snca-202 60731573-60829855 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000114268ENSMUST00000163779
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000114268 0.400±0.06 0.387±0.22 0.728±0.11 29.337±16.48 0.322±0.00 0.311±0.02 11.911±10.31 1.491±0.49 148.798±108.71 1.972±0.93 0.473±0.10 0.814±0.27 8.545±4.66 0.155±0.00
ENSMUST00000163779 0.380±0.18 0.306±0.14 0.276±0.06 15.778±12.15 0.532±0.19 0.405±0.17 3.028±1.56 0.990±0.44 0.326±0.08 3.097±1.16 0.191±0.06 0.549±0.29 0.378±0.00 0.127±0.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000KO CIL_0000KO_0002 CGP 6:60731573-60989378

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001774 IMP microglial cell activation
GO:0001921 IEA positive regulation of receptor recycling
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001956 IDA positive regulation of neurotransmitter secretion
GO:0001963 IMP synaptic transmission, dopaminergic
GO:0005507 ISS copper ion binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005543 IEA phospholipid binding
GO:0005634 IDA nucleus
GO:0005640 IEA nuclear outer membrane
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005791 IEA rough endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005840 IEA ribosome
GO:0005856 IDA cytoskeleton
GO:0005886 IDA plasma membrane
GO:0005938 IEA cell cortex
GO:0006631 IMP fatty acid metabolic process
GO:0006638 IMP neutral lipid metabolic process
GO:0006644 IMP phospholipid metabolic process
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006 IMP mitochondrial membrane organization
GO:0007268 IGI synaptic transmission
GO:0007568 IEA aging
GO:0008017 IEA microtubule binding
GO:0008021 IEA synaptic vesicle
GO:0008198 IEA ferrous iron binding
GO:0008270 IEA zinc ion binding
GO:0008344 IGI adult locomotory behavior
GO:0010040 IEA response to iron(II) ion
GO:0010517 IEA regulation of phospholipase activity
GO:0010642 IEA negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048 IMP regulation of glutamate secretion
GO:0014059 IGI regulation of dopamine secretion
GO:0015629 IEA actin cytoskeleton
GO:0016234 IDA inclusion body
GO:0016491 IEA oxidoreductase activity
GO:0019894 IEA kinesin binding
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030424 IEA axon
GO:0030426 IEA growth cone
GO:0030544 IEA Hsp70 protein binding
GO:0030659 IEA cytoplasmic vesicle membrane
GO:0031092 IEA platelet alpha granule membrane
GO:0031115 IEA negative regulation of microtubule polymerization
GO:0031623 IEA receptor internalization
GO:0031648 IEA protein destabilization
GO:0032026 IEA response to magnesium ion
GO:0032410 IEA negative regulation of transporter activity
GO:0032496 IEA response to lipopolysaccharide
GO:0032769 IEA negative regulation of monooxygenase activity
GO:0033138 IMP positive regulation of peptidyl-serine phosphorylation
GO:0034341 IEA response to interferon-gamma
GO:0034599 IMP cellular response to oxidative stress
GO:0035067 IEA negative regulation of histone acetylation
GO:0040012 IMP regulation of locomotion
GO:0042220 IEA response to cocaine
GO:0042393 IDA histone binding
GO:0042416 IMP dopamine biosynthetic process
GO:0042417 IGI dopamine metabolic process
GO:0042493 IMP response to drug
GO:0042775 IMP mitochondrial ATP synthesis coupled electron transport
GO:0042802 IDA identical protein binding
GO:0043014 IEA alpha-tubulin binding
GO:0043027 IEA cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043030 IMP regulation of macrophage activation
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043195 IEA terminal bouton
GO:0043205 IEA fibril
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043274 IEA phospholipase binding
GO:0043524 IGI negative regulation of neuron apoptotic process
GO:0043679 IEA axon terminus
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0045202 IDA synapse
GO:0045502 IEA dynein binding
GO:0045807 IEA positive regulation of endocytosis
GO:0045920 IEA negative regulation of exocytosis
GO:0045963 IEA negative regulation of dopamine metabolic process
GO:0046928 IMP regulation of neurotransmitter secretion
GO:0047485 IEA protein N-terminus binding
GO:0048148 IEA behavioral response to cocaine
GO:0048156 IEA tau protein binding
GO:0048168 IMP regulation of neuronal synaptic plasticity
GO:0048169 IMP regulation of long-term neuronal synaptic plasticity
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048487 IEA beta-tubulin binding
GO:0048488 IMP synaptic vesicle endocytosis
GO:0048489 IMP synaptic vesicle transport
GO:0050544 IDA arachidonic acid binding
GO:0050806 IMP positive regulation of synaptic transmission
GO:0050808 IGI synapse organization
GO:0050812 IMP regulation of acyl-CoA biosynthetic process
GO:0051219 IEA phosphoprotein binding
GO:0051281 IEA positive regulation of release of sequestered calcium ion into cytosol
GO:0051585 IEA negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612 IEA negative regulation of serotonin uptake
GO:0051622 IEA negative regulation of norepinephrine uptake
GO:0055114 IEA oxidation-reduction process
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0060291 IMP long-term synaptic potentiation
GO:0060732 IEA positive regulation of inositol phosphate biosynthetic process
GO:0061024 IMP membrane organization
GO:0070495 IEA negative regulation of thrombin receptor signaling pathway
GO:0070555 IEA response to interleukin-1
GO:0071280 IEA cellular response to copper ion
GO:0071902 IEA positive regulation of protein serine/threonine kinase activity
GO:1901214 IEA regulation of neuron death
GO:1903284 IEA positive regulation of glutathione peroxidase activity
GO:1903285 IEA positive regulation of hydrogen peroxide catabolic process
GO:2000377 IMP regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000145335 SNCA synuclein, alpha (non A4 component of amyloid precursor) protein_coding Homo_sapiens

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