C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 5-hydroxytryptamine (serotonin) receptor 2B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026228 Htr2b 10090 - 1:86099026-86111970 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027431 Htr2b-001 86099026-86111970 protein_coding
  ENSMUST00000155077 Htr2b-002 86100101-86110672 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00076M CIL_00076M_0002 CGP 1:86045863-86139151
CIL_0004KX CIL_0004KX_0003 CGP 1:86064387-86139151

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001755 IMP neural crest cell migration
GO:0001819 ISS positive regulation of cytokine production
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0001965 ISS G-protein alpha-subunit binding
GO:0002031 IDA G-protein coupled receptor internalization
GO:0003007 IMP heart morphogenesis
GO:0003300 IMP cardiac muscle hypertrophy
GO:0004993 TAS serotonin receptor activity
GO:0005099 IMP Ras GTPase activator activity
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006182 ISS cGMP biosynthetic process
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006939 IEA smooth muscle contraction
GO:0007186 ISS G-protein coupled receptor signaling pathway
GO:0007202 IEA activation of phospholipase C activity
GO:0007205 IMP protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007208 TAS phospholipase C-activating serotonin receptor signaling pathway
GO:0007210 ISS serotonin receptor signaling pathway
GO:0007507 IMP heart development
GO:0007610 IEA behavior
GO:0008144 IDA drug binding
GO:0008284 ISS positive regulation of cell proliferation
GO:0010507 ISS negative regulation of autophagy
GO:0010513 ISS positive regulation of phosphatidylinositol biosynthetic process
GO:0014033 IMP neural crest cell differentiation
GO:0014065 ISS phosphatidylinositol 3-kinase signaling
GO:0014827 ISS intestine smooth muscle contraction
GO:0016021 IEA integral component of membrane
GO:0016310 ISS phosphorylation
GO:0019722 ISS calcium-mediated signaling
GO:0030054 IEA cell junction
GO:0032320 IMP positive regulation of Ras GTPase activity
GO:0042310 ISS vasoconstriction
GO:0042493 IDA response to drug
GO:0043005 IEA neuron projection
GO:0043066 IMP negative regulation of apoptotic process
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0045202 IEA synapse
GO:0048598 IMP embryonic morphogenesis
GO:0050715 IMP positive regulation of cytokine secretion
GO:0050795 IMP regulation of behavior
GO:0051000 ISS positive regulation of nitric-oxide synthase activity
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0051378 IDA serotonin binding
GO:0051781 IMP positive regulation of cell division
GO:0060548 ISS negative regulation of cell death
GO:0070371 IMP ERK1 and ERK2 cascade
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070528 ISS protein kinase C signaling
GO:0071502 IDA cellular response to temperature stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070940 htr2b 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled protein_coding Danio_rerio
ENSG00000135914 HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled protein_coding Homo_sapiens

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