C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: disabled 2 interacting protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026883 Dab2ip 10090 + 2:35558266-35730994 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000065001 Dab2ip-004 35691994-35730992 protein_coding
  ENSMUST00000091010 Dab2ip-006 35622037-35730987 protein_coding
  ENSMUST00000112981 Dab2ip-005 35661541-35730994 nonsense_mediated_decay
  ENSMUST00000112983 Dab2ip-001 35696732-35730992 protein_coding
  ENSMUST00000112986 Dab2ip-003 35558266-35730994 protein_coding
  ENSMUST00000112987 Dab2ip-002 35581060-35730992 protein_coding
  ENSMUST00000112992 Dab2ip-011 35622160-35730992 protein_coding
  ENSMUST00000124098 Dab2ip-010 35692333-35728947 protein_coding
  ENSMUST00000135741 Dab2ip-009 35582840-35730992 protein_coding
  ENSMUST00000138957 Dab2ip-007 35661619-35709933 processed_transcript
  ENSMUST00000145698 Dab2ip-008 35621981-35730992 nonsense_mediated_decay
  ENSMUST00000156465 Dab2ip-013 35661350-35708847 retained_intron
  ENSMUST00000156669 Dab2ip-012 35710327-35730994 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000065001ENSMUST00000091010ENSMUST00000112983ENSMUST00000112986ENSMUST00000112987ENSMUST00000124098ENSMUST00000135741ENSMUST00000145698ENSMUST00000156669
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000065001 6.513±0.63 5.404±0.00 N/A N/A 4.603±0.73 12.025±1.05 1.472±0.00 2.374±0.63 0.894±0.35 11.246±0.32 N/A 5.095±0.55 4.005±3.46 N/A
ENSMUST00000091010 4.999±0.17 7.772±1.84 N/A N/A 4.198±0.49 5.470±0.04 2.676±0.48 1.790±0.27 0.738±0.23 6.328±0.91 2.709±0.77 6.929±0.80 1.297±0.00 N/A
ENSMUST00000112983 16.453±3.12 17.139±3.08 18.750±1.46 15.150±0.72 8.031±3.34 18.397±3.07 4.938±1.28 4.919±1.01 1.219±0.50 12.713±1.83 1.605±0.00 10.387±1.63 5.314±0.46 N/A
ENSMUST00000112986 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.428±0.03 N/A N/A N/A
ENSMUST00000112987 N/A N/A 9.163±1.48 5.802±0.26 N/A N/A N/A N/A 0.766±0.18 N/A 7.195±3.41 N/A 1.669±0.00 2.357±0.37
ENSMUST00000124098 N/A N/A N/A 12.809±5.02 N/A 11.533±0.51 N/A N/A N/A N/A N/A 7.443±1.58 N/A 2.812±0.81
ENSMUST00000135741 N/A N/A N/A N/A N/A N/A N/A 2.353±0.00 N/A 7.033±0.00 N/A N/A 10.343±0.00 2.651±0.00
ENSMUST00000145698 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.489±0.01 N/A N/A N/A
ENSMUST00000156669 8.020±0.08 18.844±1.99 N/A 9.595±0.38 7.325±3.70 16.056±3.74 4.110±0.19 3.883±1.14 0.765±0.20 12.264±0.79 N/A 8.595±1.54 2.419±0.00 2.552±0.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006N4 CIL_0006N4_0002 CGP 2:35558266-35979913

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000185 ISS activation of MAPKKK activity
GO:0001525 IEA angiogenesis
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0005099 IBA Ras GTPase activator activity
GO:0005123 IEA death receptor binding
GO:0005515 IPI protein binding
GO:0005737 IBA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006954 IEA inflammatory response
GO:0006986 IEA response to unfolded protein
GO:0007049 IEA cell cycle
GO:0007165 IEA signal transduction
GO:0007252 IMP I-kappaB phosphorylation
GO:0007257 IEA activation of JUN kinase activity
GO:0008285 ISS negative regulation of cell proliferation
GO:0008625 IEA extrinsic apoptotic signaling pathway via death domain receptors
GO:0010596 IMP negative regulation of endothelial cell migration
GO:0010633 ISS negative regulation of epithelial cell migration
GO:0010719 ISS negative regulation of epithelial to mesenchymal transition
GO:0010976 IMP positive regulation of neuron projection development
GO:0014067 ISS negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016525 IMP negative regulation of angiogenesis
GO:0017124 ISS SH3 domain binding
GO:0019900 IEA kinase binding
GO:0019901 IEA protein kinase binding
GO:0021814 IMP cell motility involved in cerebral cortex radial glia guided migration
GO:0021819 IMP layer formation in cerebral cortex
GO:0030139 ISS endocytic vesicle
GO:0030424 IDA axon
GO:0030948 IMP negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031235 IBA intrinsic component of the cytoplasmic side of the plasma membrane
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032266 ISS phosphatidylinositol-3-phosphate binding
GO:0032312 IMP regulation of ARF GTPase activity
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0032403 ISS protein complex binding
GO:0032809 IDA neuronal cell body membrane
GO:0034144 ISS negative regulation of toll-like receptor 4 signaling pathway
GO:0034260 IMP negative regulation of GTPase activity
GO:0034261 ISS negative regulation of Ras GTPase activity
GO:0035148 IMP tube formation
GO:0035414 IMP negative regulation of catenin import into nucleus
GO:0035591 IEA signaling adaptor activity
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0036312 ISS phosphatidylinositol 3-kinase regulatory subunit binding
GO:0036324 IMP vascular endothelial growth factor receptor-2 signaling pathway
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043025 IDA neuronal cell body
GO:0043065 IMP positive regulation of apoptotic process
GO:0043122 IMP regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 ISS negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043184 IEA vascular endothelial growth factor receptor 2 binding
GO:0043254 IMP regulation of protein complex assembly
GO:0043407 ISS negative regulation of MAP kinase activity
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0043548 ISS phosphatidylinositol 3-kinase binding
GO:0043553 ISS negative regulation of phosphatidylinositol 3-kinase activity
GO:0044257 ISS cellular protein catabolic process
GO:0044300 IDA cerebellar mossy fiber
GO:0044301 IDA climbing fiber
GO:0045087 IEA innate immune response
GO:0045732 IMP positive regulation of protein catabolic process
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046330 ISS positive regulation of JNK cascade
GO:0046580 IBA negative regulation of Ras protein signal transduction
GO:0048147 IMP negative regulation of fibroblast proliferation
GO:0048812 IMP neuron projection morphogenesis
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050680 ISS negative regulation of epithelial cell proliferation
GO:0051721 IEA protein phosphatase 2A binding
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070062 IEA extracellular vesicular exosome
GO:0070273 ISS phosphatidylinositol-4-phosphate binding
GO:0070317 ISS negative regulation of G0 to G1 transition
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0071158 ISS positive regulation of cell cycle arrest
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071347 IDA cellular response to interleukin-1
GO:0071356 IMP cellular response to tumor necrosis factor
GO:0071889 IEA 14-3-3 protein binding
GO:0071901 IMP negative regulation of protein serine/threonine kinase activity
GO:0071902 IMP positive regulation of protein serine/threonine kinase activity
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0090129 IMP positive regulation of synapse maturation
GO:1900006 IMP positive regulation of dendrite development
GO:1900744 IMP regulation of p38MAPK cascade
GO:1900747 IDA negative regulation of vascular endothelial growth factor signaling pathway
GO:1901800 ISS positive regulation of proteasomal protein catabolic process
GO:1990032 IDA parallel fiber
GO:2000599 ISS negative regulation of cyclin catabolic process
GO:2001224 IMP positive regulation of neuron migration
GO:2001235 ISS positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069484 dab2ipa DAB2 interacting protein a protein_coding Danio_rerio
ENSDARG00000075110 dab2ipb DAB2 interacting protein b protein_coding Danio_rerio
ENSG00000136848 DAB2IP DAB2 interacting protein protein_coding Homo_sapiens

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