C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin 1 beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027398 Il1b 10090 - 2:129364570-129371139 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028881 Il1b-001 129364570-129371139 protein_coding
  ENSMUST00000141979 Il1b-002 129365122-129367351 processed_transcript
  ENSMUST00000155994 Il1b-003 129369729-129371139 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028881ENSMUST00000141979ENSMUST00000155994
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028881 0.167±0.13 0.181±0.06 0.089±0.02 0.024±0.02 0.411±0.17 0.247±0.12 0.311±0.09 0.338±0.13 0.332±0.23 2.440±1.27 0.115±0.08 0.428±0.61 0.412±0.30 0.374±0.00
ENSMUST00000141979 N/A N/A N/A N/A N/A N/A N/A N/A 0.261±0.10 N/A N/A N/A N/A N/A
ENSMUST00000155994 0.167±0.12 0.132±0.00 N/A 0.013±0.00 0.109±0.00 N/A 0.150±0.00 N/A 0.126±0.02 N/A 0.063±0.00 0.303±0.06 N/A 0.538±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018X CIL_00018X_0002 CGP 2:129299610-129371139

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 IEA activation of MAPK activity
GO:0001660 IEA fever generation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0005125 IDA cytokine activity
GO:0005149 IEA interleukin-1 receptor binding
GO:0005615 IDA extracellular space
GO:0006955 IEA immune response
GO:0008285 IEA negative regulation of cell proliferation
GO:0009743 IDA response to carbohydrate
GO:0010575 IMP positive regulation vascular endothelial growth factor production
GO:0010628 IDA positive regulation of gene expression
GO:0010829 IDA negative regulation of glucose transport
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019904 IEA protein domain specific binding
GO:0030141 IDA secretory granule
GO:0030213 IEA hyaluronan biosynthetic process
GO:0030593 IDA neutrophil chemotaxis
GO:0030730 IEA sequestering of triglyceride
GO:0031622 IDA positive regulation of fever generation
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0031982 IDA vesicle
GO:0032308 IDA positive regulation of prostaglandin secretion
GO:0032496 IDA response to lipopolysaccharide
GO:0032611 IGI interleukin-1 beta production
GO:0032725 IEA positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0033198 IDA response to ATP
GO:0034116 IEA positive regulation of heterotypic cell-cell adhesion
GO:0035234 IGI ectopic germ cell programmed cell death
GO:0035505 IEA positive regulation of myosin light chain kinase activity
GO:0035690 ISO cellular response to drug
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042346 IEA positive regulation of NF-kappaB import into nucleus
GO:0043122 IEA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407 IDA negative regulation of MAP kinase activity
GO:0043491 IEA protein kinase B signaling
GO:0045080 IDA positive regulation of chemokine biosynthetic process
GO:0045086 IEA positive regulation of interleukin-2 biosynthetic process
GO:0045410 IDA positive regulation of interleukin-6 biosynthetic process
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045766 IMP positive regulation of angiogenesis
GO:0045833 IDA negative regulation of lipid metabolic process
GO:0045840 IEA positive regulation of mitosis
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IDA positive regulation of JNK cascade
GO:0046627 IDA negative regulation of insulin receptor signaling pathway
GO:0050796 IEA regulation of insulin secretion
GO:0050900 IDA leukocyte migration
GO:0050995 IEA negative regulation of lipid catabolic process
GO:0050996 IDA positive regulation of lipid catabolic process
GO:0051044 IEA positive regulation of membrane protein ectodomain proteolysis
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051781 IEA positive regulation of cell division
GO:0060559 IEA positive regulation of calcidiol 1-monooxygenase activity
GO:0070164 IDA negative regulation of adiponectin secretion
GO:0070487 IEA monocyte aggregation
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071310 ISO cellular response to organic substance
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071639 IEA positive regulation of monocyte chemotactic protein-1 production
GO:0097192 IMP extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005419 il1b interleukin 1, beta protein_coding Danio_rerio
ENSG00000125538 IL1B interleukin 1, beta protein_coding Homo_sapiens

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