C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027523 Gnas 10090 + 2:174284320-174346744 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000080493 Gnas-004 174297859-174346502 protein_coding
  ENSMUST00000087871 Gnas-002 174327768-174346744 protein_coding
  ENSMUST00000087876 Gnas-020 174297859-174346744 protein_coding
  ENSMUST00000087877 Gnas-006 174297859-174302018 protein_coding
  ENSMUST00000109083 Gnas-018 174330287-174338084 protein_coding
  ENSMUST00000109084 Gnas-017 174330097-174346744 protein_coding
  ENSMUST00000109085 Gnas-014 174330006-174346744 protein_coding
  ENSMUST00000109087 Gnas-201 174330089-174346712 protein_coding
  ENSMUST00000109088 Gnas-019 174297859-174346502 protein_coding
  ENSMUST00000109095 Gnas-008 174284320-174296895 protein_coding
  ENSMUST00000109096 Gnas-007 174284320-174346744 protein_coding
  ENSMUST00000124935 Gnas-015 174327570-174345241 processed_transcript
  ENSMUST00000129534 Gnas-012 174344650-174345728 retained_intron
  ENSMUST00000130761 Gnas-013 174285358-174338084 protein_coding
  ENSMUST00000130940 Gnas-009 174285256-174345540 protein_coding
  ENSMUST00000131125 Gnas-011 174341704-174345409 retained_intron
  ENSMUST00000133356 Gnas-010 174327757-174338084 processed_transcript
  ENSMUST00000148640 Gnas-016 174328023-174345279 processed_transcript
  ENSMUST00000149016 Gnas-003 174327730-174328947 processed_transcript
  ENSMUST00000154658 Gnas-005 174297859-174346502 processed_transcript
  ENSMUST00000156623 Gnas-001 174327699-174346502 processed_transcript
  ENSMUST00000180362 Gnas-202 174284320-174338084 protein_coding
  ENSMUST00000185956 Gnas-203 174297859-174346712 protein_coding
  ENSMUST00000186907 Gnas-204 174297859-174346712 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENSMUST00000109085ENSMUST00000130940ENSMUST00000131125ENSMUST00000148640
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENSMUST00000109085 N/A 110.997±20.43 N/A N/A N/A 41.501±1.39 N/A N/A N/A N/A 60.124±6.61 N/A N/A
ENSMUST00000130940 N/A N/A N/A N/A N/A 169.044±0.00 N/A 133.407±0.00 N/A N/A 293.700±34.37 N/A N/A
ENSMUST00000131125 464.106±17.17 N/A 404.876±24.36 825.898±319.68 329.172±25.71 N/A 250.414±5.52 N/A 219.953±25.30 384.905±23.87 574.151±95.13 522.879±128.09 N/A
ENSMUST00000148640 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 257.327±32.21 37.064±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00073J CIL_00073J_0002 CGP 2:174110349-174346744

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IMP skeletal system development
GO:0001894 IMP tissue homeostasis
GO:0001958 IMP endochondral ossification
GO:0003924 IBA GTPase activity
GO:0004871 IBA signal transducer activity
GO:0005159 IBA insulin-like growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005525 IEA GTP binding
GO:0005576 IEA extracellular region
GO:0005834 IBA heterotrimeric G-protein complex
GO:0006112 IMP energy reserve metabolic process
GO:0006184 IEA GTP catabolic process
GO:0006306 IMP DNA methylation
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007189 IDA adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007191 IGI adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007606 IBA sensory perception of chemical stimulus
GO:0009791 IMP post-embryonic development
GO:0016020 IDA membrane
GO:0019001 IEA guanyl nucleotide binding
GO:0030425 IDA dendrite
GO:0030819 ISS positive regulation of cAMP biosynthetic process
GO:0031410 IEA cytoplasmic vesicle
GO:0031683 IBA G-protein beta/gamma-subunit complex binding
GO:0031698 IBA beta-2 adrenergic receptor binding
GO:0031748 IBA D1 dopamine receptor binding
GO:0031852 IBA mu-type opioid receptor binding
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0035116 IMP embryonic hindlimb morphogenesis
GO:0035255 IBA ionotropic glutamate receptor binding
GO:0035264 IMP multicellular organism growth
GO:0040015 IMP negative regulation of multicellular organism growth
GO:0040032 IMP post-embryonic body morphogenesis
GO:0042493 IMP response to drug
GO:0043588 IMP skin development
GO:0043950 ISS positive regulation of cAMP-mediated signaling
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045672 IMP positive regulation of osteoclast differentiation
GO:0046872 IEA metal ion binding
GO:0048589 IEA developmental growth
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0050890 IEA cognition
GO:0051216 IMP cartilage development
GO:0051430 IBA corticotropin-releasing hormone receptor 1 binding
GO:0060348 IEA bone development
GO:0060789 IEA hair follicle placode formation
GO:0070062 IEA extracellular vesicular exosome
GO:0070527 IEA platelet aggregation
GO:0071514 IMP genetic imprinting
GO:0071880 ISS adenylate cyclase-activating adrenergic receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043094 gnas GNAS complex locus protein_coding Danio_rerio
ENSG00000087460 GNAS GNAS complex locus protein_coding Homo_sapiens

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