C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027665 Pik3ca 10090 + 3:32397671-32468486 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029201 Pik3ca-201 32436151-32468486 protein_coding
  ENSMUST00000108242 Pik3ca-002 32436376-32466107 protein_coding
  ENSMUST00000108243 Pik3ca-001 32397671-32466107 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000108242ENSMUST00000108243
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000108242 1.129±0.00 1.289±0.35 1.785±0.00 3.461±1.21 1.295±0.00 2.780±0.75 0.579±0.00 2.037±1.39 1.363±0.49 3.939±2.01 1.906±0.17 4.119±1.12 3.125±1.70 1.931±0.00
ENSMUST00000108243 6.307±1.27 2.062±0.70 8.720±1.27 5.496±1.68 4.485±0.87 1.471±0.21 3.663±0.42 5.086±1.69 2.222±0.92 5.676±2.07 3.368±0.76 2.876±2.54 5.947±1.49 2.402±0.85

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001FJ CIL_0001FJ_0002 CGP 3:32334796-32468486
CIL_0001FK CIL_0001FK_0002 CGP 3:32397671-32491969

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005886 IBA plasma membrane
GO:0005942 IPI phosphatidylinositol 3-kinase complex
GO:0005943 IEA phosphatidylinositol 3-kinase complex, class IA
GO:0006006 IMP glucose metabolic process
GO:0006468 IDA protein phosphorylation
GO:0016303 IDA 1-phosphatidylinositol-3-kinase activity
GO:0030027 IDA lamellipodium
GO:0030295 IDA protein kinase activator activity
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0035005 IBA 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0036092 IDA phosphatidylinositol-3-phosphate biosynthetic process
GO:0040014 IMP regulation of multicellular organism growth
GO:0043491 IMP protein kinase B signaling
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043560 IPI insulin receptor substrate binding
GO:0044029 IDA hypomethylation of CpG island
GO:0045860 IDA positive regulation of protein kinase activity
GO:0046854 IEA phosphatidylinositol phosphorylation
GO:0046934 IBA phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048015 IEA phosphatidylinositol-mediated signaling
GO:2000270 IDA negative regulation of fibroblast apoptotic process
GO:2000653 IDA regulation of genetic imprinting
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075456 PIK3CA (1 of 2) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein_coding Danio_rerio
ENSDARG00000075947 PIK3CA (2 of 2) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein_coding Danio_rerio
ENSG00000121879 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein_coding Homo_sapiens

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