C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000108243 Pik3ca-001 ENSMUSG00000027665 10090 + 3:32397671-32466107 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000108243
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000108243 6.307±1.27 2.062±0.70 8.720±1.27 5.496±1.68 4.485±0.87 1.471±0.21 3.663±0.42 5.086±1.69 2.222±0.92 5.676±2.07 3.368±0.76 2.876±2.54 5.947±1.49 2.402±0.85

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001FJ CIL_0001FJ_0002 CGP 3:32334796-32468486
CIL_0001FK CIL_0001FK_0002 CGP 3:32397671-32491969

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005886 IBA plasma membrane
GO:0005942 IPI phosphatidylinositol 3-kinase complex
GO:0006006 IMP glucose metabolic process
GO:0006468 IDA protein phosphorylation
GO:0016303 IDA 1-phosphatidylinositol-3-kinase activity
GO:0030027 IDA lamellipodium
GO:0030295 IDA protein kinase activator activity
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0035005 IBA 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0036092 IDA phosphatidylinositol-3-phosphate biosynthetic process
GO:0040014 IMP regulation of multicellular organism growth
GO:0043491 IMP protein kinase B signaling
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043560 IPI insulin receptor substrate binding
GO:0044029 IDA hypomethylation of CpG island
GO:0045860 IDA positive regulation of protein kinase activity
GO:0046934 IBA phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048015 IEA phosphatidylinositol-mediated signaling
GO:2000270 IDA negative regulation of fibroblast apoptotic process
GO:2000653 IDA regulation of genetic imprinting

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000149115 protein_coding Danio_rerio 0 1048
ENST00000263967 PIK3CA-001 protein_coding Homo_sapiens 0 4835
ENST00000462255 PIK3CA-004 retained_intron Homo_sapiens 0 948
ENST00000468036 PIK3CA-003 protein_coding Homo_sapiens 0 529
ENST00000477735 PIK3CA-002 protein_coding Homo_sapiens 3e-27 124
ENST00000485523 KCNMB3-001 protein_coding Homo_sapiens 0 302
ENST00000493696 KCNMB3P1-001 transcribed_unprocessed_pseudogene Homo_sapiens 1.4013e-45 189

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