C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: disabled 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028519 Dab1 10090 + 4:103619359-104744844 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000106826 Dab1-005 104512073-104680382 protein_coding
  ENSMUST00000106827 Dab1-002 103619665-104680382 protein_coding
  ENSMUST00000106830 Dab1-001 104367590-104744844 protein_coding
  ENSMUST00000141037 Dab1-007 104591218-104678792 processed_transcript
  ENSMUST00000143294 Dab1-004 103619359-104178521 processed_transcript
  ENSMUST00000143644 Dab1-006 104367113-104679496 protein_coding
  ENSMUST00000146078 Dab1-003 104367590-104741797 nonsense_mediated_decay
  ENSMUST00000149672 Dab1-008 104605296-104713800 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000106826ENSMUST00000106827ENSMUST00000106830ENSMUST00000143294ENSMUST00000143644ENSMUST00000146078ENSMUST00000149672
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000106826 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.185±0.00
ENSMUST00000106827 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.248±0.00
ENSMUST00000106830 0.012±0.00 0.081±0.02 19.505±4.79 0.125±0.11 0.278±0.06 N/A 0.750±0.14 0.057±0.01 0.071±0.02 0.015±0.01 0.654±0.40 0.200±0.02 0.276±0.19
ENSMUST00000143294 N/A 0.217±0.04 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000143644 N/A N/A N/A 0.140±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000146078 1.505±0.00 0.299±0.17 N/A 0.231±0.15 0.441±0.21 0.010±0.00 0.914±0.30 0.058±0.04 0.113±0.08 0.027±0.01 3.040±1.02 1.261±0.06 0.325±0.15
ENSMUST00000149672 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.072±0.04 0.991±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001764 IGI neuron migration
GO:0005515 IPI protein binding
GO:0005543 TAS phospholipid binding
GO:0005622 TAS intracellular
GO:0005829 IEA cytosol
GO:0005903 IEA brush border
GO:0007162 IMP negative regulation of cell adhesion
GO:0007264 IMP small GTPase mediated signal transduction
GO:0007399 NAS nervous system development
GO:0007417 TAS central nervous system development
GO:0007420 IEA brain development
GO:0007494 IEA midgut development
GO:0007628 IMP adult walking behavior
GO:0014069 IEA postsynaptic density
GO:0016020 IEA membrane
GO:0016358 IGI dendrite development
GO:0021517 IEP ventral spinal cord development
GO:0021589 IMP cerebellum structural organization
GO:0021795 IMP cerebral cortex cell migration
GO:0021799 IMP cerebral cortex radially oriented cell migration
GO:0021813 IMP cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
GO:0021942 IMP radial glia guided migration of Purkinje cell
GO:0021987 IEA cerebral cortex development
GO:0035556 TAS intracellular signal transduction
GO:0042169 TAS SH2 domain binding
GO:0042493 IEA response to drug
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0045177 IEA apical part of cell
GO:0045666 IMP positive regulation of neuron differentiation
GO:0045860 IGI positive regulation of protein kinase activity
GO:0046426 IMP negative regulation of JAK-STAT cascade
GO:0048471 IGI perinuclear region of cytoplasm
GO:0048712 IMP negative regulation of astrocyte differentiation
GO:0050771 IGI negative regulation of axonogenesis
GO:0051645 IMP Golgi localization
GO:0097477 IMP lateral motor column neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003290 dab1b disabled homolog 1b (Drosophila) protein_coding Danio_rerio
ENSDARG00000059939 dab1a disabled homolog 1a (Drosophila) protein_coding Danio_rerio
ENSG00000173406 DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) protein_coding Homo_sapiens

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