C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nitric oxide synthase 3, endothelial cell
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028978 Nos3 10090 + 5:24364810-24384474 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000030834 Nos3-001 24364810-24384474 protein_coding
  ENSMUST00000115090 Nos3-002 24364810-24384327 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000030834ENSMUST00000115090
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000030834 14.060±5.67 11.282±2.53 3.560±0.05 3.370±0.38 16.599±7.17 2.100±0.41 8.339±2.68 4.091±0.44 1.197±0.36 8.222±1.54 2.243±0.72 7.339±2.45 1.468±0.41 0.972±0.00
ENSMUST00000115090 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.193±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T1 CIL_0008T1_0002 VISTA 5:24041638-24646055
CIL_0004OG CIL_0004OG_0002 CGP 5:24319589-24384474
CIL_0004OH CIL_0004OH_0002 CGP 5:24364810-24392143

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0001542 IMP ovulation from ovarian follicle
GO:0001701 IMP in utero embryonic development
GO:0001974 IMP blood vessel remodeling
GO:0002028 IMP regulation of sodium ion transport
GO:0003057 IGI regulation of the force of heart contraction by chemical signal
GO:0003100 IEA regulation of systemic arterial blood pressure by endothelin
GO:0003785 IEA actin monomer binding
GO:0003958 IBA NADPH-hemoprotein reductase activity
GO:0004517 IMP nitric-oxide synthase activity
GO:0005506 IEA iron ion binding
GO:0005515 IEA protein binding
GO:0005516 IEA calmodulin binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 IBA cytosol
GO:0005856 IEA cytoskeleton
GO:0005901 IEA caveola
GO:0006527 IEA arginine catabolic process
GO:0006809 IMP nitric oxide biosynthetic process
GO:0007263 IBA nitric oxide mediated signal transduction
GO:0008285 IMP negative regulation of cell proliferation
GO:0010181 IEA FMN binding
GO:0014740 IMP negative regulation of muscle hyperplasia
GO:0014806 IMP smooth muscle hyperplasia
GO:0020037 IEA heme binding
GO:0030324 IMP lung development
GO:0031284 IBA positive regulation of guanylate cyclase activity
GO:0031663 IMP lipopolysaccharide-mediated signaling pathway
GO:0034405 IEA response to fluid shear stress
GO:0034617 IEA tetrahydrobiopterin binding
GO:0034618 IEA arginine binding
GO:0043267 IMP negative regulation of potassium ion transport
GO:0043542 IEA endothelial cell migration
GO:0045766 IMP positive regulation of angiogenesis
GO:0045776 IBA negative regulation of blood pressure
GO:0045909 IBA positive regulation of vasodilation
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0050661 IEA NADP binding
GO:0050880 IMP regulation of blood vessel size
GO:0051346 IMP negative regulation of hydrolase activity
GO:0051926 IMP negative regulation of calcium ion transport
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000164867 NOS3 nitric oxide synthase 3 (endothelial cell) protein_coding Homo_sapiens

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