C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: purinergic receptor P2X, ligand-gated ion channel, 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029468 P2rx7 10090 + 5:122643911-122691432 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000031425 P2rx7-003 122643939-122691432 protein_coding
  ENSMUST00000086247 P2rx7-004 122644009-122655262 protein_coding
  ENSMUST00000100737 P2rx7-001 122643911-122684289 protein_coding
  ENSMUST00000121489 P2rx7-002 122643911-122684297 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000031425ENSMUST00000086247ENSMUST00000100737ENSMUST00000121489
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000031425 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.159±0.00 0.854±0.00 N/A N/A
ENSMUST00000086247 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.144±0.00 N/A
ENSMUST00000100737 6.678±2.59 1.010±0.13 4.862±0.07 0.721±0.26 4.781±0.90 2.724±0.97 0.932±0.37 0.609±0.26 0.464±0.16 6.676±0.45 0.329±0.08 4.491±1.39 0.220±0.13 0.856±0.44
ENSMUST00000121489 1.275±0.00 N/A N/A N/A 2.109±0.43 1.184±0.00 0.489±0.19 0.292±0.08 0.291±0.17 2.408±0.00 0.178±0.00 1.168±0.11 0.281±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZL CIL_0002ZL_0002 CGP 5:122643911-122729738

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0000287 IEA magnesium ion binding
GO:0000902 IMP cell morphogenesis
GO:0001530 IDA lipopolysaccharide binding
GO:0001614 IBA purinergic nucleotide receptor activity
GO:0001845 IMP phagolysosome assembly
GO:0001916 IMP positive regulation of T cell mediated cytotoxicity
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0002028 IEA regulation of sodium ion transport
GO:0004872 IMP receptor activity
GO:0004931 IMP extracellular ATP-gated cation channel activity
GO:0005102 IEA receptor binding
GO:0005507 IEA copper ion binding
GO:0005515 IPI protein binding
GO:0005524 IMP ATP binding
GO:0005639 IBA integral component of nuclear inner membrane
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IMP integral component of plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IMP protein phosphorylation
GO:0006509 IMP membrane protein ectodomain proteolysis
GO:0006649 IMP phospholipid transfer to membrane
GO:0006812 IMP cation transport
GO:0006816 IMP calcium ion transport
GO:0006884 IDA cell volume homeostasis
GO:0006900 IMP membrane budding
GO:0006954 IMP inflammatory response
GO:0007005 IDA mitochondrion organization
GO:0007009 IDA plasma membrane organization
GO:0007166 IEA cell surface receptor signaling pathway
GO:0008270 IEA zinc ion binding
GO:0009612 IMP response to mechanical stimulus
GO:0009617 IMP response to bacterium
GO:0009897 IDA external side of plasma membrane
GO:0010033 IMP response to organic substance
GO:0010043 IMP response to zinc ion
GO:0010467 IMP gene expression
GO:0010524 IEA positive regulation of calcium ion transport into cytosol
GO:0012501 IMP programmed cell death
GO:0014049 IMP positive regulation of glutamate secretion
GO:0014054 IMP positive regulation of gamma-aminobutyric acid secretion
GO:0014070 IDA response to organic cyclic compound
GO:0015267 IMP channel activity
GO:0016020 IDA membrane
GO:0016079 IMP synaptic vesicle exocytosis
GO:0016485 IMP protein processing
GO:0019228 IEA neuronal action potential
GO:0019233 IMP sensory perception of pain
GO:0019835 IMP cytolysis
GO:0030501 IMP positive regulation of bone mineralization
GO:0031594 IDA neuromuscular junction
GO:0031668 IMP cellular response to extracellular stimulus
GO:0032059 IEA bleb
GO:0032060 IMP bleb assembly
GO:0032308 IMP positive regulation of prostaglandin secretion
GO:0032496 IMP response to lipopolysaccharide
GO:0032731 IMP positive regulation of interleukin-1 beta production
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0032963 IMP collagen metabolic process
GO:0033198 IMP response to ATP
GO:0034405 IMP response to fluid shear stress
GO:0035590 IEA purinergic nucleotide receptor signaling pathway
GO:0042098 IMP T cell proliferation
GO:0042493 IMP response to drug
GO:0043005 IEA neuron projection
GO:0043025 IDA neuronal cell body
GO:0043029 IMP T cell homeostasis
GO:0043065 IMP positive regulation of apoptotic process
GO:0043085 IMP positive regulation of catalytic activity
GO:0043132 IMP NAD transport
GO:0043195 IEA terminal bouton
GO:0043234 IEA protein complex
GO:0043409 IDA negative regulation of MAPK cascade
GO:0043410 IMP positive regulation of MAPK cascade
GO:0044254 IDA multicellular organismal protein catabolic process
GO:0045121 IEA membrane raft
GO:0045202 IDA synapse
GO:0045332 IDA phospholipid translocation
GO:0045778 IMP positive regulation of ossification
GO:0045779 IMP negative regulation of bone resorption
GO:0045919 IEA positive regulation of cytolysis
GO:0046513 IDA ceramide biosynthetic process
GO:0046931 IMP pore complex assembly
GO:0048705 IMP skeletal system morphogenesis
GO:0048873 IMP homeostasis of number of cells within a tissue
GO:0050714 IDA positive regulation of protein secretion
GO:0050715 IMP positive regulation of cytokine secretion
GO:0050717 IMP positive regulation of interleukin-1 alpha secretion
GO:0050718 IMP positive regulation of interleukin-1 beta secretion
GO:0050830 IMP defense response to Gram-positive bacterium
GO:0051209 IMP release of sequestered calcium ion into cytosol
GO:0051259 IDA protein oligomerization
GO:0051495 IEA positive regulation of cytoskeleton organization
GO:0051592 IDA response to calcium ion
GO:0051602 IMP response to electrical stimulus
GO:0051899 IEA membrane depolarization
GO:0051901 IMP positive regulation of mitochondrial depolarization
GO:0055085 IMP transmembrane transport
GO:0070230 IMP positive regulation of lymphocyte apoptotic process
GO:0072593 IMP reactive oxygen species metabolic process
GO:0097110 IEA scaffold protein binding
GO:0097190 IEA apoptotic signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:0098655 IMP cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042440 p2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 protein_coding Danio_rerio
ENSG00000089041 P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7 protein_coding Homo_sapiens

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