C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: purinergic receptor P2X, ligand-gated ion channel, 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000031425 P2rx7-003 ENSMUSG00000029468 10090 + 5:122643939-122691432 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; MuscleOvaryENSMUST00000031425
Transcript ID Muscle Ovary
ENSMUST00000031425 0.159±0.00 0.854±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZL CIL_0002ZL_0002 CGP 5:122643911-122729738

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0000902 IMP cell morphogenesis
GO:0001530 IDA lipopolysaccharide binding
GO:0001614 IBA purinergic nucleotide receptor activity
GO:0001845 IMP phagolysosome assembly
GO:0001916 IMP positive regulation of T cell mediated cytotoxicity
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0004872 IMP receptor activity
GO:0004931 IMP extracellular ATP-gated cation channel activity
GO:0005515 IPI protein binding
GO:0005524 IMP ATP binding
GO:0005639 IBA integral component of nuclear inner membrane
GO:0005886 IDA plasma membrane
GO:0005887 IMP integral component of plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IMP protein phosphorylation
GO:0006509 IMP membrane protein ectodomain proteolysis
GO:0006649 IMP phospholipid transfer to membrane
GO:0006812 IMP cation transport
GO:0006816 IMP calcium ion transport
GO:0006884 IDA cell volume homeostasis
GO:0006900 IMP membrane budding
GO:0006954 IMP inflammatory response
GO:0007005 IDA mitochondrion organization
GO:0007009 IDA plasma membrane organization
GO:0009612 IMP response to mechanical stimulus
GO:0009617 IMP response to bacterium
GO:0009897 IDA external side of plasma membrane
GO:0010033 IMP response to organic substance
GO:0010043 IMP response to zinc ion
GO:0010467 IMP gene expression
GO:0012501 IMP programmed cell death
GO:0014049 IMP positive regulation of glutamate secretion
GO:0014054 IMP positive regulation of gamma-aminobutyric acid secretion
GO:0014070 IDA response to organic cyclic compound
GO:0015267 IMP channel activity
GO:0016020 IDA membrane
GO:0016079 IMP synaptic vesicle exocytosis
GO:0016485 IMP protein processing
GO:0019835 IMP cytolysis
GO:0030501 IMP positive regulation of bone mineralization
GO:0031594 IDA neuromuscular junction
GO:0031668 IMP cellular response to extracellular stimulus
GO:0032060 IMP bleb assembly
GO:0032308 IMP positive regulation of prostaglandin secretion
GO:0032496 IMP response to lipopolysaccharide
GO:0032731 IMP positive regulation of interleukin-1 beta production
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0032963 IMP collagen metabolic process
GO:0033198 IMP response to ATP
GO:0034405 IMP response to fluid shear stress
GO:0035590 IEA purinergic nucleotide receptor signaling pathway
GO:0042098 IMP T cell proliferation
GO:0042493 IMP response to drug
GO:0043025 IDA neuronal cell body
GO:0043029 IMP T cell homeostasis
GO:0043065 IMP positive regulation of apoptotic process
GO:0043085 IMP positive regulation of catalytic activity
GO:0043132 IMP NAD transport
GO:0043409 IDA negative regulation of MAPK cascade
GO:0043410 IMP positive regulation of MAPK cascade
GO:0044254 IDA multicellular organismal protein catabolic process
GO:0045202 IDA synapse
GO:0045332 IDA phospholipid translocation
GO:0045778 IMP positive regulation of ossification
GO:0045779 IMP negative regulation of bone resorption
GO:0046513 IDA ceramide biosynthetic process
GO:0046931 IMP pore complex assembly
GO:0048705 IMP skeletal system morphogenesis
GO:0048873 IMP homeostasis of number of cells within a tissue
GO:0050714 IDA positive regulation of protein secretion
GO:0050715 IMP positive regulation of cytokine secretion
GO:0050717 IMP positive regulation of interleukin-1 alpha secretion
GO:0050718 IMP positive regulation of interleukin-1 beta secretion
GO:0050830 IMP defense response to Gram-positive bacterium
GO:0051209 IMP release of sequestered calcium ion into cytosol
GO:0051259 IDA protein oligomerization
GO:0051592 IDA response to calcium ion
GO:0051602 IMP response to electrical stimulus
GO:0051901 IMP positive regulation of mitochondrial depolarization
GO:0055085 IMP transmembrane transport
GO:0070230 IMP positive regulation of lymphocyte apoptotic process
GO:0072593 IMP reactive oxygen species metabolic process
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:0098655 IMP cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000261826 P2RX7-011 nonsense_mediated_decay Homo_sapiens 0 433
ENST00000328963 P2RX7-008 protein_coding Homo_sapiens 0 1144
ENST00000535250 P2RX7-002 nonsense_mediated_decay Homo_sapiens 0 957
ENST00000535600 P2RX7-005 nonsense_mediated_decay Homo_sapiens 0 564
ENST00000539695 P2RX7-006 retained_intron Homo_sapiens 0 435
ENST00000541022 P2RX7-009 nonsense_mediated_decay Homo_sapiens 0 361
ENST00000541564 P2RX7-010 nonsense_mediated_decay Homo_sapiens 0 660
ENST00000541716 P2RX7-007 nonsense_mediated_decay Homo_sapiens 0 361

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