C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aprataxin and PNKP like factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030051 Aplf 10090 - 6:87628429-87672168 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000032130 Aplf-201 87628429-87672168 protein_coding
  ENSMUST00000065997 Aplf-202 87628429-87672168 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000032130ENSMUST00000065997
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000032130 1.549±0.64 1.674±0.20 0.563±0.00 0.797±0.12 1.130±0.08 1.562±0.70 0.464±0.06 0.849±0.38 0.712±0.21 1.829±0.23 0.176±0.02 2.390±1.00 1.982±0.00 0.862±0.12
ENSMUST00000065997 N/A N/A 0.366±0.00 1.115±0.82 N/A 0.671±0.00 N/A N/A 1.068±0.47 N/A 0.243±0.07 1.828±0.87 0.957±0.60 0.626±0.25

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000012 ISS single strand break repair
GO:0000166 ISS nucleotide binding
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0003906 ISS DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520 ISS endodeoxyribonuclease activity
GO:0005634 ISS nucleus
GO:0005737 IEA cytoplasm
GO:0006302 ISS double-strand break repair
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0008408 ISS 3'-5' exonuclease activity
GO:0035861 IEA site of double-strand break
GO:0045191 IMP regulation of isotype switching
GO:0046872 IEA metal ion binding
GO:0051106 IEA positive regulation of DNA ligation
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000086579 APLF aprataxin and PNKP like factor protein_coding Danio_rerio
ENSG00000169621 APLF aprataxin and PNKP like factor protein_coding Homo_sapiens

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