C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: low density lipoprotein receptor-related protein 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030201 Lrp6 10090 - 6:134446476-134566965 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000032322 Lrp6-001 134446476-134566913 protein_coding
  ENSMUST00000111950 Lrp6-003 134450483-134471293 protein_coding
  ENSMUST00000126836 Lrp6-002 134511284-134566965 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000032322ENSMUST00000111950ENSMUST00000126836
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000032322 10.365±5.02 13.499±1.90 12.825±2.77 6.366±1.07 9.792±4.36 19.356±3.19 6.684±0.44 17.947±3.06 5.264±2.61 17.126±1.23 4.330±0.91 16.125±2.43 8.069±0.97 1.591±0.30
ENSMUST00000111950 N/A N/A N/A N/A N/A 6.746±0.00 N/A N/A N/A N/A N/A 6.597±0.54 4.464±0.00 N/A
ENSMUST00000126836 N/A 17.059±3.48 N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.725±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003HK CIL_0003HK_0002 CGP 6:134396318-134566965
CIL_0006X9 CIL_0006X9_0003 CGP 6:134446476-134632488

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001702 IGI gastrulation with mouth forming second
GO:0001756 IGI somitogenesis
GO:0001843 IMP neural tube closure
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001947 IGI heart looping
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0003344 IGI pericardium morphogenesis
GO:0003401 IMP axis elongation
GO:0005041 IBA low-density lipoprotein receptor activity
GO:0005102 IEA receptor binding
GO:0005109 IEA frizzled binding
GO:0005515 IPI protein binding
GO:0005769 IDA early endosome
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 ISO plasma membrane
GO:0005901 IBA caveola
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006469 IEA negative regulation of protein kinase activity
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007268 IBA synaptic transmission
GO:0009880 IMP embryonic pattern specification
GO:0009950 IMP dorsal/ventral axis specification
GO:0009952 IGI anterior/posterior pattern specification
GO:0009986 IBA cell surface
GO:0014029 IBA neural crest formation
GO:0014033 IEA neural crest cell differentiation
GO:0015026 IBA coreceptor activity
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016055 IGI Wnt signaling pathway
GO:0016337 IEA single organismal cell-cell adhesion
GO:0017147 IPI Wnt-protein binding
GO:0019210 IEA kinase inhibitor activity
GO:0019534 IMP toxin transporter activity
GO:0021587 IMP cerebellum morphogenesis
GO:0021794 IMP thalamus development
GO:0021795 IMP cerebral cortex cell migration
GO:0021861 IGI forebrain radial glial cell differentiation
GO:0021872 IMP forebrain generation of neurons
GO:0021874 IGI Wnt signaling pathway involved in forebrain neuroblast division
GO:0021915 IGI neural tube development
GO:0021943 IGI formation of radial glial scaffolds
GO:0021987 IMP cerebral cortex development
GO:0030178 IGI negative regulation of Wnt signaling pathway
GO:0030326 IGI embryonic limb morphogenesis
GO:0030900 IMP forebrain development
GO:0030901 IMP midbrain development
GO:0030917 IMP midbrain-hindbrain boundary development
GO:0031410 IEA cytoplasmic vesicle
GO:0034392 IEA negative regulation of smooth muscle cell apoptotic process
GO:0035108 IMP limb morphogenesis
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0035116 IGI embryonic hindlimb morphogenesis
GO:0035261 IMP external genitalia morphogenesis
GO:0036342 IMP post-anal tail morphogenesis
GO:0042074 IGI cell migration involved in gastrulation
GO:0042127 IMP regulation of cell proliferation
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042733 IGI embryonic digit morphogenesis
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0042813 IBA Wnt-activated receptor activity
GO:0043025 IBA neuronal cell body
GO:0043065 IMP positive regulation of apoptotic process
GO:0043235 IBA receptor complex
GO:0043434 IEA response to peptide hormone
GO:0044332 IBA Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045202 IBA synapse
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045778 IMP positive regulation of ossification
GO:0045780 IMP positive regulation of bone resorption
GO:0045787 IEA positive regulation of cell cycle
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IBA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IGI bone remodeling
GO:0048596 IMP embryonic camera-type eye morphogenesis
GO:0048699 IMP generation of neurons
GO:0048705 IMP skeletal system morphogenesis
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051593 IMP response to folic acid
GO:0060021 IMP palate development
GO:0060026 IGI convergent extension
GO:0060042 IMP retina morphogenesis in camera-type eye
GO:0060059 IMP embryonic retina morphogenesis in camera-type eye
GO:0060070 IMP:ISS canonical Wnt signaling pathway
GO:0060284 IMP regulation of cell development
GO:0060325 IMP face morphogenesis
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0060535 IGI trachea cartilage morphogenesis
GO:0060596 IMP mammary placode formation
GO:0060603 IGI mammary gland duct morphogenesis
GO:0061310 IMP canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0061324 IMP canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0071397 IEA cellular response to cholesterol
GO:0071542 IMP dopaminergic neuron differentiation
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity
GO:0071936 IEA coreceptor activity involved in Wnt signaling pathway
GO:0090009 IGI primitive streak formation
GO:0090118 IMP receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090244 IMP Wnt signaling pathway involved in somitogenesis
GO:0090245 IGI axis elongation involved in somitogenesis
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway
GO:1901998 IEA toxin transport
GO:2000051 IGI negative regulation of non-canonical Wnt signaling pathway
GO:2000055 IEA positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000149 IGI negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:2000151 IGI negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162 IGI negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000164 IGI negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166 IGI negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000168 IGI negative regulation of planar cell polarity pathway involved in neural tube closure

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076053 lrp6 low-density lipoprotein receptor-related protein 6 protein_coding Danio_rerio
ENSG00000070018 LRP6 low density lipoprotein receptor-related protein 6 protein_coding Homo_sapiens

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