C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: low density lipoprotein receptor-related protein 6
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000111950 Lrp6-003 ENSMUSG00000030201 10090 - 6:134450483-134471293 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonOvaryPlacentaENSMUST00000111950
Transcript ID Colon Ovary Placenta
ENSMUST00000111950 6.746±0.00 6.597±0.54 4.464±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003HK CIL_0003HK_0002 CGP 6:134396318-134566965
CIL_0006X9 CIL_0006X9_0003 CGP 6:134446476-134632488

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001702 IGI gastrulation with mouth forming second
GO:0001756 IGI somitogenesis
GO:0001843 IMP neural tube closure
GO:0001947 IGI heart looping
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0003344 IGI pericardium morphogenesis
GO:0003401 IMP axis elongation
GO:0005041 IBA low-density lipoprotein receptor activity
GO:0005515 IPI protein binding
GO:0005769 IDA early endosome
GO:0005886 ISO plasma membrane
GO:0005901 IBA caveola
GO:0007268 IBA synaptic transmission
GO:0009880 IMP embryonic pattern specification
GO:0009950 IMP dorsal/ventral axis specification
GO:0009952 IGI anterior/posterior pattern specification
GO:0009986 IBA cell surface
GO:0014029 IBA neural crest formation
GO:0015026 IBA coreceptor activity
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016055 IGI Wnt signaling pathway
GO:0017147 IPI Wnt-protein binding
GO:0021587 IMP cerebellum morphogenesis
GO:0021794 IMP thalamus development
GO:0021795 IMP cerebral cortex cell migration
GO:0021861 IGI forebrain radial glial cell differentiation
GO:0021872 IMP forebrain generation of neurons
GO:0021874 IGI Wnt signaling pathway involved in forebrain neuroblast division
GO:0021915 IGI neural tube development
GO:0021943 IGI formation of radial glial scaffolds
GO:0021987 IMP cerebral cortex development
GO:0030178 IGI negative regulation of Wnt signaling pathway
GO:0030326 IGI embryonic limb morphogenesis
GO:0030900 IMP forebrain development
GO:0030901 IMP midbrain development
GO:0030917 IMP midbrain-hindbrain boundary development
GO:0035108 IMP limb morphogenesis
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0035116 IGI embryonic hindlimb morphogenesis
GO:0035261 IMP external genitalia morphogenesis
GO:0036342 IMP post-anal tail morphogenesis
GO:0042074 IGI cell migration involved in gastrulation
GO:0042127 IMP regulation of cell proliferation
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042733 IGI embryonic digit morphogenesis
GO:0042813 IBA Wnt-activated receptor activity
GO:0043025 IBA neuronal cell body
GO:0043065 IMP positive regulation of apoptotic process
GO:0043235 IBA receptor complex
GO:0044332 IBA Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045202 IBA synapse
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045778 IMP positive regulation of ossification
GO:0045780 IMP positive regulation of bone resorption
GO:0045944 IBA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IGI bone remodeling
GO:0048596 IMP embryonic camera-type eye morphogenesis
GO:0048699 IMP generation of neurons
GO:0048705 IMP skeletal system morphogenesis
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051593 IMP response to folic acid
GO:0060021 IMP palate development
GO:0060026 IGI convergent extension
GO:0060042 IMP retina morphogenesis in camera-type eye
GO:0060059 IMP embryonic retina morphogenesis in camera-type eye
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060284 IMP regulation of cell development
GO:0060325 IMP face morphogenesis
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0060535 IGI trachea cartilage morphogenesis
GO:0060596 IMP mammary placode formation
GO:0060603 IGI mammary gland duct morphogenesis
GO:0061310 IMP canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0061324 IMP canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0071542 IMP dopaminergic neuron differentiation
GO:0090009 IGI primitive streak formation
GO:0090118 IMP receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090244 IMP Wnt signaling pathway involved in somitogenesis
GO:0090245 IGI axis elongation involved in somitogenesis
GO:2000051 IGI negative regulation of non-canonical Wnt signaling pathway
GO:2000149 IGI negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:2000151 IGI negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162 IGI negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000164 IGI negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166 IGI negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000168 IGI negative regulation of planar cell polarity pathway involved in neural tube closure

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000261349 LRP6-001 protein_coding Homo_sapiens 0 3068
ENST00000538239 LRP6-003 nonsense_mediated_decay Homo_sapiens 0 2715
ENST00000540415 LRP6-005 processed_transcript Homo_sapiens 0 518
ENST00000540527 LRP6-006 protein_coding Homo_sapiens 6e-38 161
ENST00000543091 LRP6-004 protein_coding Homo_sapiens 0 1315

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