C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endoplasmic reticulum (ER) to nucleus signalling 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030866 Ern2 10090 - 7:122169893-122186216 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033153 Ern2-201 122169893-122186216 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000033153
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000033153 0.020±0.00 0.014±0.00 0.685±0.02 0.192±0.15 0.035±0.02 51.377±18.67 0.189±0.01 0.068±0.01 0.023±0.02 0.245±0.16 0.034±0.01 0.016±0.01 0.070±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003VD CIL_0003VD_0003 CGP 7:122159437-122186216
CIL_0006CZ CIL_0006CZ_0002 CGP 7:122169893-122222824

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0004519 IEA endonuclease activity
GO:0004540 IEA ribonuclease activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005524 ISS ATP binding
GO:0005783 IEA endoplasmic reticulum
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006397 IEA mRNA processing
GO:0006468 ISS protein phosphorylation
GO:0006987 ISS activation of signaling protein activity involved in unfolded protein response
GO:0007050 IDA cell cycle arrest
GO:0016021 IEA integral component of membrane
GO:0016075 IEA rRNA catabolic process
GO:0030263 IEA apoptotic chromosome condensation
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0070059 IDA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis
GO:0090501 IEA RNA phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058475 ern2 endoplasmic reticulum to nucleus signaling 2 protein_coding Danio_rerio
ENSG00000134398 ERN2 endoplasmic reticulum to nucleus signaling 2 protein_coding Homo_sapiens

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