C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: caspase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031628 Casp3 10090 + 8:46617449-46638706 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000093517 Casp3-201 46617449-46638706 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENSMUST00000093517
Transcript ID Adipose Adrenal Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000093517 2.007±0.83 1.868±0.19 23.606±22.50 3.797±0.00 5.695±3.47 0.642±0.17 22.904±11.08 1.933±1.10 0.378±0.00 4.175±1.21 1.797±0.00 0.503±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097G CIL_00097G_0002 VISTA 8:46470571-47072246
CIL_00094W CIL_00094W_0002 VISTA 8:46548055-47151393

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001782 IMP B cell homeostasis
GO:0001836 IGI release of cytochrome c from mitochondria
GO:0004190 IDA aspartic-type endopeptidase activity
GO:0004197 IDA cysteine-type endopeptidase activity
GO:0004252 TAS serine-type endopeptidase activity
GO:0004861 IMP cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006508 RCA proteolysis
GO:0006915 IDA apoptotic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007507 IGI heart development
GO:0007605 IMP sensory perception of sound
GO:0008233 IMP peptidase activity
GO:0008234 IDA cysteine-type peptidase activity
GO:0008625 IMP extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631 IDA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411 IDA response to UV
GO:0009611 IDA response to wounding
GO:0016485 IDA protein processing
GO:0030182 IBA neuron differentiation
GO:0030216 IMP keratinocyte differentiation
GO:0030218 IBA erythrocyte differentiation
GO:0030889 IMP negative regulation of B cell proliferation
GO:0034349 IMP glial cell apoptotic process
GO:0043029 IMP T cell homeostasis
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043525 IDA positive regulation of neuron apoptotic process
GO:0045165 IMP cell fate commitment
GO:0045736 IMP negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 IMP negative regulation of cell cycle
GO:0046007 IMP negative regulation of activated T cell proliferation
GO:0051402 IMP neuron apoptotic process
GO:0071310 IDA cellular response to organic substance
GO:0097153 IDA cysteine-type endopeptidase activity involved in apoptotic process
GO:0097192 IDA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 IMP execution phase of apoptosis
GO:0097200 IDA cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902510 IMP regulation of apoptotic DNA fragmentation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017905 casp3a caspase 3, apoptosis-related cysteine protease a protein_coding Danio_rerio
ENSDARG00000055045 casp3b caspase 3, apoptosis-related cysteine protease b protein_coding Danio_rerio
ENSG00000164305 CASP3 caspase 3, apoptosis-related cysteine peptidase protein_coding Homo_sapiens

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