C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: guanine nucleotide binding protein, alpha O
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031748 Gnao1 10090 + 8:93809966-93969388 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034198 Gnao1-001 93810838-93969388 protein_coding
  ENSMUST00000125695 Gnao1-004 93810636-93811767 retained_intron
  ENSMUST00000125716 Gnao1-002 93810840-93968956 protein_coding
  ENSMUST00000127900 Gnao1-007 93896231-93968163 nonsense_mediated_decay
  ENSMUST00000130974 Gnao1-008 93949505-93950675 retained_intron
  ENSMUST00000137202 Gnao1-006 93809966-93950403 protein_coding
  ENSMUST00000138659 Gnao1-003 93811313-93957497 processed_transcript
  ENSMUST00000142466 Gnao1-011 93950405-93968060 protein_coding
  ENSMUST00000144451 Gnao1-009 93952947-93956580 processed_transcript
  ENSMUST00000149530 Gnao1-005 93950405-93968081 protein_coding
  ENSMUST00000155245 Gnao1-010 93962844-93967021 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034198ENSMUST00000125695ENSMUST00000125716ENSMUST00000127900ENSMUST00000137202ENSMUST00000138659ENSMUST00000155245
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034198 1.178±0.00 N/A 8.031±1.29 41.583±7.33 N/A N/A 2.195±0.96 0.273±0.00 0.051±0.02 N/A 1.359±0.22 N/A 0.050±0.00 3.770±0.00
ENSMUST00000125695 N/A N/A N/A N/A 0.480±0.01 0.973±0.05 N/A N/A 0.033±0.01 N/A N/A 1.676±0.34 0.404±0.00 N/A
ENSMUST00000125716 1.409±0.70 1.721±0.15 11.167±3.43 42.813±15.67 0.550±0.31 1.945±0.42 3.557±1.30 0.377±0.13 0.070±0.04 2.721±0.09 0.776±0.23 1.742±0.49 0.249±0.13 1.787±0.00
ENSMUST00000127900 N/A N/A N/A N/A 1.635±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000137202 N/A N/A N/A 232.008±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.472±0.00 N/A
ENSMUST00000138659 N/A N/A 4.445±0.00 40.212±0.00 N/A 1.750±0.00 N/A 0.494±0.00 0.058±0.03 N/A 0.582±0.09 N/A 0.453±0.28 N/A
ENSMUST00000155245 N/A N/A N/A N/A N/A N/A N/A N/A 0.189±0.15 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00048R CIL_00048R_0002 CGP 8:93499213-93969388
CIL_00048U CIL_00048U_0002 CGP 8:93809966-94012663

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003924 TAS:IDA GTPase activity
GO:0004871 IBA signal transducer activity
GO:0005515 IPI protein binding
GO:0005525 IMP GTP binding
GO:0005622 IDA intracellular
GO:0005834 IBA heterotrimeric G-protein complex
GO:0005886 TAS plasma membrane
GO:0006184 IEA GTP catabolic process
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007188 IBA adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212 IMP dopamine receptor signaling pathway
GO:0007568 IEA aging
GO:0007626 IMP locomotory behavior
GO:0008016 IMP regulation of heart contraction
GO:0009987 IMP cellular process
GO:0010243 IEA response to organonitrogen compound
GO:0014070 IEA response to organic cyclic compound
GO:0016020 TAS membrane
GO:0030900 IEA forebrain development
GO:0031175 IEA neuron projection development
GO:0031683 IBA G-protein beta/gamma-subunit complex binding
GO:0031821 IBA G-protein coupled serotonin receptor binding
GO:0031852 IBA mu-type opioid receptor binding
GO:0032403 IEA protein complex binding
GO:0032794 IEA GTPase activating protein binding
GO:0034097 IEA response to cytokine
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0043005 IEA neuron projection
GO:0043234 IEA protein complex
GO:0043278 IEA response to morphine
GO:0043547 IEA positive regulation of GTPase activity
GO:0046872 IEA metal ion binding
GO:0051430 IBA corticotropin-releasing hormone receptor 1 binding
GO:0051926 IEA negative regulation of calcium ion transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016676 gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a protein_coding Danio_rerio
ENSDARG00000036058 gnao1b guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b protein_coding Danio_rerio
ENSG00000087258 GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O protein_coding Homo_sapiens

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