C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087258 GNAO1 9606 + 16:56191390-56357444 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262493 GNAO1-001 56191390-56357444 protein_coding
  ENST00000262494 GNAO1-002 56191976-56348199 protein_coding
  ENST00000562316 GNAO1-011 56193653-56334857 protein_coding
  ENST00000563440 GNAO1-008 56226379-56334775 protein_coding
  ENST00000563661 GNAO1-004 56192239-56276428 retained_intron
  ENST00000564727 GNAO1-007 56351441-56355208 protein_coding
  ENST00000564798 GNAO1-003 56340296-56348135 retained_intron
  ENST00000565363 GNAO1-005 56192493-56334776 protein_coding
  ENST00000568375 GNAO1-006 56336746-56355121 processed_transcript
  ENST00000569295 GNAO1-009 56192014-56213407 processed_transcript
  ENST00000570235 GNAO1-010 56191975-56192694 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262493ENST00000262494ENST00000562316ENST00000563440ENST00000563661ENST00000564798ENST00000570235
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262493 0.119±0.00 0.451±0.00 0.056±0.00 40.950±13.60 0.058±0.00 4.390±0.00 0.793±0.60 0.742±0.51 0.273±0.00 0.159±0.00 0.156±0.00 0.197±0.09 0.150±0.00 7.025±0.00
ENST00000262494 0.538±0.00 1.542±0.00 N/A 19.837±16.99 0.358±0.01 6.234±5.36 1.494±1.20 0.545±0.27 0.859±0.00 0.033±0.00 0.326±0.07 0.605±0.46 0.694±0.41 7.811±0.78
ENST00000562316 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.747±0.00 N/A N/A N/A N/A
ENST00000563440 N/A N/A N/A N/A 1.362±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000563661 N/A N/A 0.721±0.00 N/A N/A N/A N/A N/A N/A 0.379±0.00 N/A N/A N/A N/A
ENST00000564798 N/A N/A N/A N/A N/A N/A N/A N/A 0.499±0.00 0.168±0.00 N/A 0.151±0.04 0.198±0.00 N/A
ENST00000570235 N/A N/A N/A N/A N/A N/A 0.947±0.00 N/A N/A N/A 1.084±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00048R CIL_00048R_0001 CGP 16:55846154-56357444
CIL_00048U CIL_00048U_0001 CGP 16:56191390-56425538

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003924 IEA:IBA GTPase activity
GO:0004871 IEA:IBA signal transducer activity
GO:0005515 IEA protein binding
GO:0005525 IEA GTP binding
GO:0005622 IEA intracellular
GO:0005834 IBA heterotrimeric G-protein complex
GO:0005886 TAS plasma membrane
GO:0006184 IEA GTP catabolic process
GO:0006936 TAS muscle contraction
GO:0007165 IEA signal transduction
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007188 IEA:IBA adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212 IBA dopamine receptor signaling pathway
GO:0007568 IEA aging
GO:0007626 IEA locomotory behavior
GO:0008016 IEA regulation of heart contraction
GO:0009987 IEA cellular process
GO:0010243 IEA response to organonitrogen compound
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0019001 IEA guanyl nucleotide binding
GO:0030900 IEA forebrain development
GO:0031175 IEA neuron projection development
GO:0031683 IEA:IBA G-protein beta/gamma-subunit complex binding
GO:0031821 IBA G-protein coupled serotonin receptor binding
GO:0031852 IBA mu-type opioid receptor binding
GO:0032403 IEA protein complex binding
GO:0032794 IEA GTPase activating protein binding
GO:0034097 IEA response to cytokine
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0043005 IEA neuron projection
GO:0043234 IEA protein complex
GO:0043278 IEA response to morphine
GO:0043547 IEA positive regulation of GTPase activity
GO:0046872 IEA metal ion binding
GO:0051430 IBA corticotropin-releasing hormone receptor 1 binding
GO:0051926 IEA negative regulation of calcium ion transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016676 gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a protein_coding Danio_rerio
ENSDARG00000036058 gnao1b guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b protein_coding Danio_rerio
ENSMUSG00000031748 Gnao1 guanine nucleotide binding protein, alpha O protein_coding Mus_musculus

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