C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: metallothionein 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031760 Mt3 10090 + 8:94152607-94154148 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034211 Mt3-201 94152607-94154148 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034211
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034211 0.383±0.22 1.164±0.35 1.185±0.30 352.964±428.12 0.427±0.07 9.427±1.78 2.211±1.01 2.907±0.85 0.176±0.11 0.752±0.17 1.035±0.44 18.152±8.61 1.190±0.85 4.325±1.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00048X CIL_00048X_0002 CGP 8:94137204-94154148

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 ISS protein import into nucleus, translocation
GO:0001666 ISS response to hypoxia
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0005507 ISS copper ion binding
GO:0005515 IEA protein binding
GO:0005622 ISS intracellular
GO:0005634 ISS nucleus
GO:0005737 IEA cytoplasm
GO:0006112 IMP energy reserve metabolic process
GO:0006707 IMP cholesterol catabolic process
GO:0006829 IDA zinc ion transport
GO:0006875 IDA cellular metal ion homeostasis
GO:0006882 IDA cellular zinc ion homeostasis
GO:0006979 IMP response to oxidative stress
GO:0008021 IDA synaptic vesicle
GO:0008144 ISS drug binding
GO:0008270 IC zinc ion binding
GO:0010507 IMP negative regulation of autophagy
GO:0010628 IMP positive regulation of gene expression
GO:0010940 ISS positive regulation of necrotic cell death
GO:0010942 IMP positive regulation of cell death
GO:0014002 IDA astrocyte development
GO:0016234 ISS inclusion body
GO:0016570 ISS histone modification
GO:0019430 ISS removal of superoxide radicals
GO:0030295 ISS protein kinase activator activity
GO:0030308 ISS negative regulation of cell growth
GO:0030517 ISS negative regulation of axon extension
GO:0030949 ISS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032095 IMP regulation of response to food
GO:0032148 ISS activation of protein kinase B activity
GO:0033210 IMP leptin-mediated signaling pathway
GO:0034599 IDA cellular response to oxidative stress
GO:0035690 ISS cellular response to drug
GO:0036091 ISS positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043027 ISS cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043085 IMP positive regulation of catalytic activity
GO:0043154 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 ISS protein kinase B signaling
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0044242 IMP cellular lipid catabolic process
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0046870 ISS cadmium ion binding
GO:0046872 IDA metal ion binding
GO:0048471 ISS perinuclear region of cytoplasm
GO:0050768 IDA negative regulation of neurogenesis
GO:0050821 ISS protein stabilization
GO:0051354 ISS negative regulation of oxidoreductase activity
GO:0055069 ISS zinc ion homeostasis
GO:0055073 IMP cadmium ion homeostasis
GO:0060049 IMP regulation of protein glycosylation
GO:0060547 IMP negative regulation of necrotic cell death
GO:0070371 ISS ERK1 and ERK2 cascade
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071276 ISS cellular response to cadmium ion
GO:0071456 IEA cellular response to hypoxia
GO:0071732 ISS cellular response to nitric oxide
GO:0097214 IMP positive regulation of lysosomal membrane permeability
GO:2000117 ISS negative regulation of cysteine-type endopeptidase activity
GO:2000376 IMP positive regulation of oxygen metabolic process
GO:2000378 ISS negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000087250 MT3 metallothionein 3 protein_coding Homo_sapiens

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