C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: metallothionein 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087250 MT3 9606 + 16:56589074-56591088 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000200691 MT3-001 56589368-56591088 protein_coding
  ENST00000561640 MT3-004 56589074-56591075 protein_coding
  ENST00000565838 MT3-003 56589074-56591078 protein_coding
  ENST00000566451 MT3-002 56589536-56591085 retained_intron
  ENST00000566576 MT3-006 56589545-56591088 processed_transcript
  ENST00000570176 MT3-005 56589540-56590366 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000200691ENST00000561640ENST00000565838ENST00000566451ENST00000566576ENST00000570176
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000200691 N/A N/A 293.729±133.25 N/A 6.253±0.00 1.923±0.00 1.184±0.00 N/A 3.717±0.00 1.627±0.00 0.695±0.00 N/A 16.807±9.74
ENST00000561640 N/A N/A 51.914±0.00 N/A N/A N/A N/A 0.163±0.00 N/A N/A N/A N/A N/A
ENST00000565838 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.509±0.00 0.727±0.53 N/A
ENST00000566451 N/A N/A N/A N/A N/A N/A 0.088±0.00 N/A N/A N/A N/A N/A N/A
ENST00000566576 0.618±0.00 0.489±0.00 N/A 0.069±0.00 5.439±0.00 0.543±0.00 N/A 0.353±0.00 N/A N/A N/A 0.177±0.00 4.319±0.00
ENST00000570176 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.192±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00048X CIL_00048X_0001 CGP 16:56565049-56591088

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IDA protein import into nucleus, translocation
GO:0001666 IDA response to hypoxia
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0005507 IDA copper ion binding
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005737 IDA cytoplasm
GO:0006112 ISS energy reserve metabolic process
GO:0006707 ISS cholesterol catabolic process
GO:0006829 ISS zinc ion transport
GO:0006875 NAS cellular metal ion homeostasis
GO:0006882 ISS cellular zinc ion homeostasis
GO:0006979 IEA response to oxidative stress
GO:0008021 ISS synaptic vesicle
GO:0008144 IDA drug binding
GO:0008270 IDA zinc ion binding
GO:0008283 TAS cell proliferation
GO:0010507 ISS negative regulation of autophagy
GO:0010628 ISS positive regulation of gene expression
GO:0010940 IDA positive regulation of necrotic cell death
GO:0010942 ISS positive regulation of cell death
GO:0014002 ISS astrocyte development
GO:0016209 NAS antioxidant activity
GO:0016234 IDA inclusion body
GO:0016570 IMP histone modification
GO:0019430 IDA removal of superoxide radicals
GO:0030295 IDA protein kinase activator activity
GO:0030308 IDA negative regulation of cell growth
GO:0030517 IDA negative regulation of axon extension
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032095 ISS regulation of response to food
GO:0032148 IDA activation of protein kinase B activity
GO:0033210 ISS leptin-mediated signaling pathway
GO:0034599 IEP cellular response to oxidative stress
GO:0035690 IDA cellular response to drug
GO:0036091 IDA positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043027 IDA cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043085 ISS positive regulation of catalytic activity
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 IDA protein kinase B signaling
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0044242 ISS cellular lipid catabolic process
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046870 IDA cadmium ion binding
GO:0046872 IEA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050768 IEA negative regulation of neurogenesis
GO:0050821 IDA protein stabilization
GO:0051354 IDA negative regulation of oxidoreductase activity
GO:0055069 IDA zinc ion homeostasis
GO:0055073 IDA cadmium ion homeostasis
GO:0060049 ISS regulation of protein glycosylation
GO:0060547 ISS negative regulation of necrotic cell death
GO:0070371 IDA ERK1 and ERK2 cascade
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071276 IDA cellular response to cadmium ion
GO:0071456 IEP cellular response to hypoxia
GO:0071732 IDA cellular response to nitric oxide
GO:0097214 ISS positive regulation of lysosomal membrane permeability
GO:2000117 IDA negative regulation of cysteine-type endopeptidase activity
GO:2000376 ISS positive regulation of oxygen metabolic process
GO:2000378 IDA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000031760 Mt3 metallothionein 3 protein_coding Mus_musculus

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