C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031980 Agt 10090 - 8:124556534-124569706 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000063278 Agt-201 124556534-124569706 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000063278
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000063278 46.499±34.59 8.119±0.97 0.671±0.13 5.352±5.33 10.118±3.16 20.471±2.11 3.196±0.35 38.757±7.55 389.370±269.51 1.977±0.62 3.869±0.87 72.047±18.06 9.960±8.42 64.386±35.51

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008A0 CIL_0008A0_0002 VISTA 8:123980149-124582109
CIL_0007WK CIL_0007WK_0002 VISTA 8:124343702-124945898
CIL_000610 CIL_000610_0002 CGP 8:124520767-124569706
CIL_000615 CIL_000615_0002 CGP 8:124556534-124618731

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001543 IMP ovarian follicle rupture
GO:0001568 IMP blood vessel development
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0001822 IMP kidney development
GO:0001991 IMP regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0001998 IDA angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001999 IMP renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0002018 IMP renin-angiotensin regulation of aldosterone production
GO:0002019 IMP regulation of renal output by angiotensin
GO:0002035 IDA brain renin-angiotensin system
GO:0003014 IEA renal system process
GO:0003051 IEA angiotensin-mediated drinking behavior
GO:0003331 IEA positive regulation of extracellular matrix constituent secretion
GO:0004867 IBA serine-type endopeptidase inhibitor activity
GO:0005179 IEA hormone activity
GO:0005515 IEA protein binding
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0006883 IEA cellular sodium ion homeostasis
GO:0007160 IMP cell-matrix adhesion
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007202 IEA activation of phospholipase C activity
GO:0007250 IDA activation of NF-kappaB-inducing kinase activity
GO:0007565 IEA female pregnancy
GO:0007568 IEA aging
GO:0007588 IMP excretion
GO:0008065 IMP establishment of blood-nerve barrier
GO:0008217 IMP regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0009409 IMP response to cold
GO:0009651 IMP response to salt stress
GO:0010468 IDA regulation of gene expression
GO:0010535 IEA positive regulation of activation of JAK2 kinase activity
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0010613 IEA positive regulation of cardiac muscle hypertrophy
GO:0010628 IDA positive regulation of gene expression
GO:0010873 IEA positive regulation of cholesterol esterification
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0014061 IEA regulation of norepinephrine secretion
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014824 IEA artery smooth muscle contraction
GO:0014873 IEA response to muscle activity involved in regulation of muscle adaptation
GO:0016525 IEA negative regulation of angiogenesis
GO:0030162 IBA regulation of proteolysis
GO:0030198 IMP extracellular matrix organization
GO:0030308 IEA negative regulation of cell growth
GO:0030432 IMP peristalsis
GO:0031701 IEA angiotensin receptor binding
GO:0031702 IDA type 1 angiotensin receptor binding
GO:0031703 IPI type 2 angiotensin receptor binding
GO:0032270 IEA positive regulation of cellular protein metabolic process
GO:0032930 IEA positive regulation of superoxide anion generation
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034104 IEA negative regulation of tissue remodeling
GO:0035411 IEA catenin import into nucleus
GO:0035813 IEA regulation of renal sodium excretion
GO:0035815 IEA positive regulation of renal sodium excretion
GO:0040018 IMP positive regulation of multicellular organism growth
GO:0042310 IEA vasoconstriction
GO:0042311 IEA vasodilation
GO:0042445 IMP hormone metabolic process
GO:0042756 IMP drinking behavior
GO:0042981 IDA regulation of apoptotic process
GO:0043085 IEA positive regulation of catalytic activity
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045723 IMP positive regulation of fatty acid biosynthetic process
GO:0045742 IEA positive regulation of epidermal growth factor receptor signaling pathway
GO:0045777 IEA positive regulation of blood pressure
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045909 IEA positive regulation of vasodilation
GO:0046622 IMP positive regulation of organ growth
GO:0048143 IMP astrocyte activation
GO:0048144 IEA fibroblast proliferation
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0048659 IDA smooth muscle cell proliferation
GO:0050663 IEA cytokine secretion
GO:0050727 IDA regulation of inflammatory response
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051145 IDA smooth muscle cell differentiation
GO:0051387 IEA negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051403 IEA stress-activated MAPK cascade
GO:0051924 IEA regulation of calcium ion transport
GO:0051969 IEA regulation of transmission of nerve impulse
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0061098 IEA positive regulation of protein tyrosine kinase activity
GO:0070062 IEA extracellular vesicular exosome
GO:0070371 IEA ERK1 and ERK2 cascade
GO:0070471 IEA uterine smooth muscle contraction
GO:0071260 IEA cellular response to mechanical stimulus
GO:0072562 IEA blood microparticle
GO:0090190 IEA positive regulation of branching involved in ureteric bud morphogenesis
GO:1900020 IDA positive regulation of protein kinase C activity
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016412 agt angiotensinogen protein_coding Danio_rerio
ENSG00000135744 AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) protein_coding Homo_sapiens

Loading