C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032041 Tirap 10090 - 9:35184551-35200291 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000175765 Tirap-001 35184551-35200291 protein_coding
  ENSMUST00000176021 Tirap-005 35188729-35199883 protein_coding
  ENSMUST00000176531 Tirap-004 35186785-35199928 protein_coding
  ENSMUST00000176611 Tirap-007 35189026-35191400 protein_coding
  ENSMUST00000176685 Tirap-003 35187344-35199970 protein_coding
  ENSMUST00000177052 Tirap-006 35191037-35199499 protein_coding
  ENSMUST00000177129 Tirap-002 35186785-35199988 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderLiverLungOvaryENSMUST00000175765
Transcript ID Bladder Liver Lung Ovary
ENSMUST00000175765 5.488±0.75 6.321±1.04 6.010±0.24 6.148±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007W7 CIL_0007W7_0002 VISTA 9:35123876-35727017

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005080 IEA protein kinase C binding
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0007166 IPI cell surface receptor signaling pathway
GO:0007249 IMP I-kappaB kinase/NF-kappaB signaling
GO:0007257 ISO activation of JUN kinase activity
GO:0009617 ISO response to bacterium
GO:0030099 IMP myeloid cell differentiation
GO:0032496 IEA response to lipopolysaccharide
GO:0032738 IEA positive regulation of interleukin-15 production
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0034137 IEA positive regulation of toll-like receptor 2 signaling pathway
GO:0034145 IEA positive regulation of toll-like receptor 4 signaling pathway
GO:0035662 IEA Toll-like receptor 4 binding
GO:0035663 IEA Toll-like receptor 2 binding
GO:0035665 IEA TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130 IMP negative regulation of growth of symbiont in host
GO:0045410 IEA positive regulation of interleukin-6 biosynthetic process
GO:0046330 IEA positive regulation of JNK cascade
GO:0046982 IEA protein heterodimerization activity
GO:0050830 IMP defense response to Gram-positive bacterium
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070935 IEA 3'-UTR-mediated mRNA stabilization
GO:0071221 IMP cellular response to bacterial lipopeptide
GO:0071223 IMP cellular response to lipoteichoic acid
GO:0090073 IEA positive regulation of protein homodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074371 tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein protein_coding Danio_rerio
ENSG00000150455 TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein protein_coding Homo_sapiens

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