C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dopamine receptor D2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032259 Drd2 10090 + 9:49340662-49407214 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000075764 Drd2-201 49340662-49407214 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonHeartKidneyLungOvaryPlacentaTestisENSMUST00000075764
Transcript ID Adipose Adrenal Brain Colon Heart Kidney Lung Ovary Placenta Testis
ENSMUST00000075764 0.027±0.01 0.994±0.37 1.232±0.01 0.056±0.02 0.727±0.40 0.152±0.09 0.048±0.03 0.074±0.04 0.034±0.01 0.781±0.07

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001591 IDA dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001659 IMP temperature homeostasis
GO:0001666 IEA response to hypoxia
GO:0001669 IEA acrosomal vesicle
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0001964 IMP startle response
GO:0001975 IGI response to amphetamine
GO:0001976 IMP neurological system process involved in regulation of systemic arterial blood pressure
GO:0002027 IMP regulation of heart rate
GO:0002028 IMP regulation of sodium ion transport
GO:0002031 IEA G-protein coupled receptor internalization
GO:0002052 IDA positive regulation of neuroblast proliferation
GO:0002092 IEA positive regulation of receptor internalization
GO:0004930 IDA G-protein coupled receptor activity
GO:0004952 IDA dopamine neurotransmitter receptor activity
GO:0005102 IEA receptor binding
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007188 IEA adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194 IEA negative regulation of adenylate cyclase activity
GO:0007195 IGI adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 IGI dopamine receptor signaling pathway
GO:0007270 IMP neuron-neuron synaptic transmission
GO:0007409 IMP axonogenesis
GO:0007416 IEA synapse assembly
GO:0007608 IMP sensory perception of smell
GO:0007616 IEA long-term memory
GO:0007625 IMP grooming behavior
GO:0007626 IMP locomotory behavior
GO:0007628 IMP adult walking behavior
GO:0007631 IGI feeding behavior
GO:0008104 IMP protein localization
GO:0008144 IEA drug binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0008306 IMP associative learning
GO:0008542 IMP visual learning
GO:0009416 IMP response to light stimulus
GO:0009636 IEA response to toxic substance
GO:0010039 IEA response to iron ion
GO:0014059 IMP regulation of dopamine secretion
GO:0014069 IEA postsynaptic density
GO:0014854 IEA response to inactivity
GO:0016020 IDA membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016328 IEA lateral plasma membrane
GO:0021756 IEA striatum development
GO:0021769 IEA orbitofrontal cortex development
GO:0021853 IMP cerebral cortex GABAergic interneuron migration
GO:0021984 IMP adenohypophysis development
GO:0030139 IEA endocytic vesicle
GO:0030336 IMP negative regulation of cell migration
GO:0030424 IDA axon
GO:0030425 IDA dendrite
GO:0030432 IGI peristalsis
GO:0030534 IMP adult behavior
GO:0030672 IEA synaptic vesicle membrane
GO:0030814 IEA regulation of cAMP metabolic process
GO:0030900 IEA forebrain development
GO:0031223 IEA auditory behavior
GO:0031410 IEA cytoplasmic vesicle
GO:0032147 IEA activation of protein kinase activity
GO:0032228 IGI regulation of synaptic transmission, GABAergic
GO:0032467 IEA positive regulation of cytokinesis
GO:0032922 IMP circadian regulation of gene expression
GO:0033602 IEA negative regulation of dopamine secretion
GO:0034776 IEA response to histamine
GO:0035094 IEA response to nicotine
GO:0035240 IDA dopamine binding
GO:0035255 IEA ionotropic glutamate receptor binding
GO:0035556 IEA intracellular signal transduction
GO:0035810 IMP positive regulation of urine volume
GO:0035815 IMP positive regulation of renal sodium excretion
GO:0036126 IEA sperm flagellum
GO:0040018 IMP positive regulation of multicellular organism growth
GO:0042220 IMP response to cocaine
GO:0042321 IEA negative regulation of circadian sleep/wake cycle, sleep
GO:0042417 IMP dopamine metabolic process
GO:0042493 IMP response to drug
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043266 IMP regulation of potassium ion transport
GO:0043278 IMP response to morphine
GO:0043408 IEA regulation of MAPK cascade
GO:0043473 IMP pigmentation
GO:0043666 IEA regulation of phosphoprotein phosphatase activity
GO:0043679 IEA axon terminus
GO:0045471 IEA response to ethanol
GO:0045745 IEA positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045776 IMP negative regulation of blood pressure
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046488 IEA phosphatidylinositol metabolic process
GO:0046676 IEA negative regulation of insulin secretion
GO:0046717 IEA acid secretion
GO:0046982 IEA protein heterodimerization activity
GO:0048148 IMP behavioral response to cocaine
GO:0048149 IMP behavioral response to ethanol
GO:0048169 IMP regulation of long-term neuronal synaptic plasticity
GO:0048678 IEA response to axon injury
GO:0048755 IMP branching morphogenesis of a nerve
GO:0050482 IEA arachidonic acid secretion
GO:0050709 IEA negative regulation of protein secretion
GO:0050804 IMP regulation of synaptic transmission
GO:0051209 IEA release of sequestered calcium ion into cytosol
GO:0051481 IEA negative regulation of cytosolic calcium ion concentration
GO:0051482 IEA positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584 IMP regulation of dopamine uptake involved in synaptic transmission
GO:0051586 IMP positive regulation of dopamine uptake involved in synaptic transmission
GO:0051823 IEA regulation of synapse structural plasticity
GO:0051898 IMP negative regulation of protein kinase B signaling
GO:0051967 IMP negative regulation of synaptic transmission, glutamatergic
GO:0060124 IMP positive regulation of growth hormone secretion
GO:0060134 IMP prepulse inhibition
GO:0060158 IDA phospholipase C-activating dopamine receptor signaling pathway
GO:0060160 IMP negative regulation of dopamine receptor signaling pathway
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0090325 IEA regulation of locomotion involved in locomotory behavior
GO:1900273 IEA positive regulation of long-term synaptic potentiation
GO:1901386 IEA negative regulation of voltage-gated calcium channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011091 drd2b dopamine receptor D2b protein_coding Danio_rerio
ENSDARG00000056926 drd2a dopamine receptor D2a protein_coding Danio_rerio
ENSG00000149295 DRD2 dopamine receptor D2 protein_coding Homo_sapiens

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