C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dopamine receptor D2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000149295 DRD2 9606 - 11:113409615-113475691 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000346454 DRD2-003 113409615-113475120 protein_coding
  ENST00000362072 DRD2-001 113409615-113475389 protein_coding
  ENST00000535984 DRD2-008 113414375-113424507 processed_transcript
  ENST00000538967 DRD2-010 113410572-113424651 protein_coding
  ENST00000539420 DRD2-009 113415294-113418117 retained_intron
  ENST00000540600 DRD2-002 113413864-113475691 retained_intron
  ENST00000542616 DRD2-006 113424630-113475279 protein_coding
  ENST00000542968 DRD2-004 113409913-113424972 protein_coding
  ENST00000543292 DRD2-007 113416863-113447721 protein_coding
  ENST00000544518 DRD2-005 113409616-113424684 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLiverLungOvaryPlacentaTestisENST00000346454ENST00000362072ENST00000535984ENST00000538967ENST00000539420ENST00000542968ENST00000543292ENST00000544518
Transcript ID Adipose Adrenal Brain Breast Colon Heart Liver Lung Ovary Placenta Testis
ENST00000346454 0.069±0.00 0.021±0.00 0.229±0.00 N/A 0.063±0.00 N/A N/A 0.078±0.03 N/A 0.209±0.00 N/A
ENST00000362072 N/A N/A N/A 0.397±0.00 N/A N/A N/A N/A 0.155±0.00 N/A N/A
ENST00000535984 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.702±0.00
ENST00000538967 N/A N/A N/A N/A N/A N/A 0.097±0.00 N/A N/A N/A N/A
ENST00000539420 N/A N/A N/A N/A N/A N/A N/A N/A 0.222±0.00 N/A N/A
ENST00000542968 N/A N/A N/A N/A N/A N/A N/A N/A 0.047±0.00 N/A N/A
ENST00000543292 N/A N/A N/A N/A N/A 0.066±0.00 N/A N/A 0.078±0.00 N/A N/A
ENST00000544518 N/A N/A 0.441±0.00 N/A N/A N/A N/A N/A N/A N/A 0.227±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002BX CIL_0002BX_0002 CGP 11:113387791-113475691

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001591 IDA dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001659 ISS temperature homeostasis
GO:0001666 IEA response to hypoxia
GO:0001669 IEA acrosomal vesicle
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0001964 IEA startle response
GO:0001975 ISS response to amphetamine
GO:0001976 ISS neurological system process involved in regulation of systemic arterial blood pressure
GO:0002027 ISS regulation of heart rate
GO:0002028 ISS regulation of sodium ion transport
GO:0002031 IEA G-protein coupled receptor internalization
GO:0002052 ISS positive regulation of neuroblast proliferation
GO:0002092 IEA positive regulation of receptor internalization
GO:0004930 IEA G-protein coupled receptor activity
GO:0004952 IEA dopamine neurotransmitter receptor activity
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005887 IEA:IC integral component of plasma membrane
GO:0006874 IC cellular calcium ion homeostasis
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007188 IEA adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194 IDA negative regulation of adenylate cyclase activity
GO:0007195 IDA adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 IEA dopamine receptor signaling pathway
GO:0007270 ISS neuron-neuron synaptic transmission
GO:0007409 ISS axonogenesis
GO:0007416 ISS synapse assembly
GO:0007608 ISS sensory perception of smell
GO:0007616 IEA long-term memory
GO:0007625 IEA grooming behavior
GO:0007626 ISS locomotory behavior
GO:0007628 ISS adult walking behavior
GO:0007631 IEA feeding behavior
GO:0008104 ISS protein localization
GO:0008144 IDA drug binding
GO:0008285 ISS negative regulation of cell proliferation
GO:0008306 ISS associative learning
GO:0008542 ISS visual learning
GO:0009416 ISS response to light stimulus
GO:0009636 IEA response to toxic substance
GO:0010039 IEA response to iron ion
GO:0014059 IEA regulation of dopamine secretion
GO:0014069 IEA postsynaptic density
GO:0014854 IEA response to inactivity
GO:0015459 NAS potassium channel regulator activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016328 IEA lateral plasma membrane
GO:0021756 IEA striatum development
GO:0021769 IEA orbitofrontal cortex development
GO:0021853 ISS cerebral cortex GABAergic interneuron migration
GO:0021984 ISS adenohypophysis development
GO:0030139 IEA endocytic vesicle
GO:0030336 ISS negative regulation of cell migration
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030432 ISS peristalsis
GO:0030534 IEA adult behavior
GO:0030672 IEA synaptic vesicle membrane
GO:0030814 IDA regulation of cAMP metabolic process
GO:0030900 IEA forebrain development
GO:0031223 IEA auditory behavior
GO:0031410 IEA cytoplasmic vesicle
GO:0032147 IEA activation of protein kinase activity
GO:0032228 ISS regulation of synaptic transmission, GABAergic
GO:0032467 IMP positive regulation of cytokinesis
GO:0032922 ISS circadian regulation of gene expression
GO:0033602 IEA negative regulation of dopamine secretion
GO:0034776 IDA response to histamine
GO:0035094 IEA response to nicotine
GO:0035240 IEA dopamine binding
GO:0035255 IEA ionotropic glutamate receptor binding
GO:0035556 IDA intracellular signal transduction
GO:0035810 IEA positive regulation of urine volume
GO:0035815 IEA positive regulation of renal sodium excretion
GO:0036126 IEA sperm flagellum
GO:0040018 IEA positive regulation of multicellular organism growth
GO:0042220 ISS response to cocaine
GO:0042321 IEA negative regulation of circadian sleep/wake cycle, sleep
GO:0042417 IC dopamine metabolic process
GO:0042493 ISS response to drug
GO:0042802 IPI identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043266 ISS regulation of potassium ion transport
GO:0043278 ISS response to morphine
GO:0043408 IEA regulation of MAPK cascade
GO:0043473 IEA pigmentation
GO:0043666 IEA regulation of phosphoprotein phosphatase activity
GO:0043679 IEA axon terminus
GO:0045471 IEA response to ethanol
GO:0045745 IEA positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045776 ISS negative regulation of blood pressure
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046488 ISS phosphatidylinositol metabolic process
GO:0046676 IEA negative regulation of insulin secretion
GO:0046717 IEA acid secretion
GO:0046982 IEA protein heterodimerization activity
GO:0048148 ISS behavioral response to cocaine
GO:0048149 ISS behavioral response to ethanol
GO:0048169 ISS regulation of long-term neuronal synaptic plasticity
GO:0048678 IEA response to axon injury
GO:0048755 ISS branching morphogenesis of a nerve
GO:0050482 IDA arachidonic acid secretion
GO:0050709 IDA negative regulation of protein secretion
GO:0050804 IEA regulation of synaptic transmission
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0051481 IEA negative regulation of cytosolic calcium ion concentration
GO:0051482 IDA positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584 IC regulation of dopamine uptake involved in synaptic transmission
GO:0051586 ISS positive regulation of dopamine uptake involved in synaptic transmission
GO:0051823 IEA regulation of synapse structural plasticity
GO:0051898 ISS negative regulation of protein kinase B signaling
GO:0051967 ISS negative regulation of synaptic transmission, glutamatergic
GO:0060124 ISS positive regulation of growth hormone secretion
GO:0060134 ISS prepulse inhibition
GO:0060158 IGI phospholipase C-activating dopamine receptor signaling pathway
GO:0060160 ISS negative regulation of dopamine receptor signaling pathway
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0090325 IEA regulation of locomotion involved in locomotory behavior
GO:1900273 IEA positive regulation of long-term synaptic potentiation
GO:1901386 IDA negative regulation of voltage-gated calcium channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011091 drd2b dopamine receptor D2b protein_coding Danio_rerio
ENSDARG00000056926 drd2a dopamine receptor D2a protein_coding Danio_rerio
ENSMUSG00000032259 Drd2 dopamine receptor D2 protein_coding Mus_musculus

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