C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prostaglandin-endoperoxide synthase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032487 Ptgs2 10090 + 1:150100031-150108227 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000035065 Ptgs2-001 150100031-150108227 protein_coding
  ENSMUST00000190784 Ptgs2-003 150100332-150101326 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000035065
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000035065 0.985±0.75 0.129±0.04 2.797±0.14 0.431±0.56 0.308±0.13 2.238±0.75 0.256±0.08 0.187±0.04 0.020±0.01 2.520±0.78 0.035±0.02 0.778±0.37 1.593±0.41 2.037±0.01

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 IDA prostaglandin biosynthetic process
GO:0001525 IEA angiogenesis
GO:0004601 IEA peroxidase activity
GO:0004666 IDA prostaglandin-endoperoxide synthase activity
GO:0005737 IDA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005901 IEA caveola
GO:0006954 IEA inflammatory response
GO:0006979 IEA response to oxidative stress
GO:0007566 IEA embryo implantation
GO:0007612 IEA learning
GO:0007613 IEA memory
GO:0008217 IMP regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008289 IEA lipid binding
GO:0009314 IEA response to radiation
GO:0009750 IEA response to fructose
GO:0010033 IEA response to organic substance
GO:0010042 IEA response to manganese ion
GO:0010226 IEA response to lithium ion
GO:0010243 IEA response to organonitrogen compound
GO:0010575 IEA positive regulation vascular endothelial growth factor production
GO:0010942 IEA positive regulation of cell death
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019233 IEA sensory perception of pain
GO:0019371 IDA cyclooxygenase pathway
GO:0019899 IEA enzyme binding
GO:0020037 IDA heme binding
GO:0030216 NAS keratinocyte differentiation
GO:0030282 ISO bone mineralization
GO:0030728 IEA ovulation
GO:0031622 IDA positive regulation of fever generation
GO:0031915 IEA positive regulation of synaptic plasticity
GO:0032227 IEA negative regulation of synaptic transmission, dopaminergic
GO:0032355 IEA response to estradiol
GO:0032496 IEA response to lipopolysaccharide
GO:0033280 IEA response to vitamin D
GO:0034097 IEA response to cytokine
GO:0034612 IEA response to tumor necrosis factor
GO:0034644 IEA cellular response to UV
GO:0035633 IEA maintenance of blood-brain barrier
GO:0042127 IGI regulation of cell proliferation
GO:0042346 IEA positive regulation of NF-kappaB import into nucleus
GO:0042493 IEA response to drug
GO:0042633 IEA hair cycle
GO:0042803 IPI protein homodimerization activity
GO:0043005 IDA neuron projection
GO:0043065 IEA positive regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045786 IEA negative regulation of cell cycle
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045986 IEA negative regulation of smooth muscle contraction
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046697 IEA decidualization
GO:0046872 IEA metal ion binding
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050873 IMP brown fat cell differentiation
GO:0051384 IEA response to glucocorticoid
GO:0051926 IEA negative regulation of calcium ion transport
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0055114 IEA oxidation-reduction process
GO:0070542 IEA response to fatty acid
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071318 IEA cellular response to ATP
GO:0071456 IEA cellular response to hypoxia
GO:0071636 IEA positive regulation of transforming growth factor beta production
GO:0090050 IEA positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 IEA positive regulation of fibroblast growth factor production
GO:0090336 IMP positive regulation of brown fat cell differentiation
GO:0090362 IEA positive regulation of platelet-derived growth factor production

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004539 ptgs2a prostaglandin-endoperoxide synthase 2a protein_coding Danio_rerio
ENSDARG00000010276 ptgs2b prostaglandin-endoperoxide synthase 2b protein_coding Danio_rerio
ENSG00000073756 PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) protein_coding Homo_sapiens

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