C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000073756 PTGS2 9606 - 1:186671791-186680427 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000367468 PTGS2-001 186671791-186680427 protein_coding
  ENST00000466691 PTGS2-003 186674496-186675869 processed_transcript
  ENST00000490885 PTGS2-002 186672893-186680423 processed_transcript
  ENST00000559627 PTGS2-004 186674353-186680290 nonsense_mediated_decay
  ENST00000559800 PTGS2-005 186678270-186680423 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000367468ENST00000490885ENST00000559627
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000367468 0.157±0.00 N/A 0.760±0.28 0.524±0.00 3.571±0.00 0.103±0.02 0.151±0.05 1.116±1.04 27.460±0.00 0.118±0.00 0.737±0.84 2.270±1.55 0.314±0.24
ENST00000490885 N/A 0.328±0.00 N/A N/A N/A 0.043±0.00 N/A N/A 1.952±0.00 0.047±0.00 N/A N/A N/A
ENST00000559627 0.432±0.00 2.428±0.00 1.613±0.69 3.834±0.00 2.180±0.00 0.091±0.00 0.045±0.00 4.789±4.73 10.136±0.00 N/A 1.045±0.78 0.589±0.34 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001BQ CIL_0001BQ_0003 CGP 1:186443566-186680427
CIL_0001BP CIL_0001BP_0003 CGP 1:186671791-186988981

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 ISS prostaglandin biosynthetic process
GO:0001525 IEA angiogenesis
GO:0004601 NAS:IEA peroxidase activity
GO:0004666 IDA prostaglandin-endoperoxide synthase activity
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005901 IEA caveola
GO:0006693 TAS prostaglandin metabolic process
GO:0006928 TAS cellular component movement
GO:0006954 IEA inflammatory response
GO:0006979 IEA response to oxidative stress
GO:0007566 IEA embryo implantation
GO:0007612 IEA learning
GO:0007613 IEA memory
GO:0008217 ISS regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008289 IEA lipid binding
GO:0009314 IEA response to radiation
GO:0009750 IEA response to fructose
GO:0010033 IEA response to organic substance
GO:0010042 IEA response to manganese ion
GO:0010226 IEA response to lithium ion
GO:0010243 IEA response to organonitrogen compound
GO:0010575 ISS positive regulation vascular endothelial growth factor production
GO:0010942 IEA positive regulation of cell death
GO:0014070 IEA response to organic cyclic compound
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019233 IEA sensory perception of pain
GO:0019369 TAS arachidonic acid metabolic process
GO:0019371 IDA cyclooxygenase pathway
GO:0019372 TAS lipoxygenase pathway
GO:0019899 IPI enzyme binding
GO:0020037 ISS:IEA heme binding
GO:0030282 IEA bone mineralization
GO:0030728 IEA ovulation
GO:0031394 NAS positive regulation of prostaglandin biosynthetic process
GO:0031622 ISS positive regulation of fever generation
GO:0031915 IEA positive regulation of synaptic plasticity
GO:0032227 IEA negative regulation of synaptic transmission, dopaminergic
GO:0032355 IEA response to estradiol
GO:0032496 IEA response to lipopolysaccharide
GO:0033280 IEA response to vitamin D
GO:0034097 IEA response to cytokine
GO:0034612 IEA response to tumor necrosis factor
GO:0034644 IEA cellular response to UV
GO:0035633 IEA maintenance of blood-brain barrier
GO:0042127 IEA regulation of cell proliferation
GO:0042346 IEA positive regulation of NF-kappaB import into nucleus
GO:0042493 IEA response to drug
GO:0042633 IEA hair cycle
GO:0042803 IEA protein homodimerization activity
GO:0043005 IDA neuron projection
GO:0043065 IEA positive regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0044281 TAS small molecule metabolic process
GO:0045429 ISS positive regulation of nitric oxide biosynthetic process
GO:0045786 IEA negative regulation of cell cycle
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045986 IEA negative regulation of smooth muscle contraction
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046697 IEA decidualization
GO:0046872 IEA metal ion binding
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050473 TAS arachidonate 15-lipoxygenase activity
GO:0050727 NAS regulation of inflammatory response
GO:0050873 IEA brown fat cell differentiation
GO:0051384 IEA response to glucocorticoid
GO:0051926 IEA negative regulation of calcium ion transport
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0055114 IEA oxidation-reduction process
GO:0070542 IEA response to fatty acid
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071318 IEA cellular response to ATP
GO:0071456 IEP cellular response to hypoxia
GO:0071636 ISS positive regulation of transforming growth factor beta production
GO:0090050 ISS positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 ISS positive regulation of fibroblast growth factor production
GO:0090336 ISS positive regulation of brown fat cell differentiation
GO:0090362 ISS positive regulation of platelet-derived growth factor production

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004539 ptgs2a prostaglandin-endoperoxide synthase 2a protein_coding Danio_rerio
ENSDARG00000010276 ptgs2b prostaglandin-endoperoxide synthase 2b protein_coding Danio_rerio
ENSMUSG00000032487 Ptgs2 prostaglandin-endoperoxide synthase 2 protein_coding Mus_musculus

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