C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: scleraxis
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000034161 Scx 10090 + 15:76457438-76459468 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043089 Scx-201 76457438-76459468 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043089
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043089 2.414±1.99 33.084±13.00 1.660±0.02 1.920±0.70 1.480±0.77 5.007±0.88 2.929±1.04 3.704±0.29 0.319±0.23 13.240±1.70 4.239±0.68 23.882±8.06 0.427±0.21 1.032±0.42

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SS CIL_0007SS_0002 VISTA 15:76102685-76704351
CIL_00026T CIL_00026T_0002 CGP 15:76380261-76477269
CIL_0006M5 CIL_0006M5_0003 CGP 15:76452996-76477269
CIL_00064A CIL_00064A_0003 CGP 15:76457438-76500972

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001707 IMP mesoderm formation
GO:0001894 IMP tissue homeostasis
GO:0001958 IMP endochondral ossification
GO:0002062 IMP chondrocyte differentiation
GO:0003179 IMP heart valve morphogenesis
GO:0003188 IMP heart valve formation
GO:0003677 IDA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0006351 IDA transcription, DNA-templated
GO:0008284 IMP positive regulation of cell proliferation
GO:0010628 IMP positive regulation of gene expression
GO:0030154 IMP cell differentiation
GO:0030199 IMP collagen fibril organization
GO:0030509 IMP BMP signaling pathway
GO:0032967 IMP positive regulation of collagen biosynthetic process
GO:0035914 IMP skeletal muscle cell differentiation
GO:0035989 IMP tendon development
GO:0035990 IMP tendon cell differentiation
GO:0035992 IMP tendon formation
GO:0035993 IMP deltoid tuberosity development
GO:0043066 IMP negative regulation of apoptotic process
GO:0043425 IPI bHLH transcription factor binding
GO:0043565 IDA sequence-specific DNA binding
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0048706 IEP embryonic skeletal system development
GO:0051216 NAS cartilage development
GO:0060008 ISS Sertoli cell differentiation
GO:0060325 IEP face morphogenesis
GO:0061035 IMP regulation of cartilage development
GO:0061036 IMP positive regulation of cartilage development
GO:0061056 IEP sclerotome development
GO:0070888 IDA E-box binding
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0071773 IEP cellular response to BMP stimulus
GO:2000543 IMP positive regulation of gastrulation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011635 SCX scleraxis basic helix-loop-helix transcription factor protein_coding Danio_rerio
ENSDARG00000035695 scxa scleraxis homolog A (mouse) protein_coding Danio_rerio
ENSG00000260428 SCX scleraxis basic helix-loop-helix transcription factor protein_coding Homo_sapiens

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