C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 5-hydroxytryptamine (serotonin) receptor 2A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000034997 Htr2a 10090 + 14:74640840-74706859 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000036653 Htr2a-201 74640840-74706859 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000036653
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000036653 1.048±0.56 0.061±0.03 0.455±0.08 0.340±0.15 0.039±0.02 0.214±0.05 0.136±0.03 0.109±0.08 0.401±0.09 0.039±0.03 0.652±0.32 0.056±0.03 0.016±0.01

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001659 IEA temperature homeostasis
GO:0001965 IEA G-protein alpha-subunit binding
GO:0004993 ISO serotonin receptor activity
GO:0005515 IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006874 IEA cellular calcium ion homeostasis
GO:0007202 IEA activation of phospholipase C activity
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007208 IEA phospholipase C-activating serotonin receptor signaling pathway
GO:0007210 IEA serotonin receptor signaling pathway
GO:0007568 IEA aging
GO:0007613 IEA memory
GO:0008144 IEA drug binding
GO:0008219 IEA cell death
GO:0008284 IEA positive regulation of cell proliferation
GO:0010513 IEA positive regulation of phosphatidylinositol biosynthetic process
GO:0014059 IEA regulation of dopamine secretion
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0014824 IEA artery smooth muscle contraction
GO:0014832 IEA urinary bladder smooth muscle contraction
GO:0016020 IEA membrane
GO:0019233 IEA sensory perception of pain
GO:0030425 IEA dendrite
GO:0030431 IEA sleep
GO:0031410 IEA cytoplasmic vesicle
GO:0032403 IEA protein complex binding
GO:0033674 IMP positive regulation of kinase activity
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043198 IEA dendritic shaft
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0044380 IDA protein localization to cytoskeleton
GO:0045600 IMP positive regulation of fat cell differentiation
GO:0045821 IMP positive regulation of glycolytic process
GO:0045907 IEA positive regulation of vasoconstriction
GO:0046883 IEA regulation of hormone secretion
GO:0048148 IEA behavioral response to cocaine
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795 IEA regulation of behavior
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051209 IEA release of sequestered calcium ion into cytosol
GO:0051378 ISO serotonin binding
GO:0051967 IEA negative regulation of synaptic transmission, glutamatergic
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070852 IEA cell body fiber
GO:0071886 IEA 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057029 htr2a 5-hydroxytryptamine (serotonin) receptor 2A protein_coding Danio_rerio
ENSDARG00000058165 HTR2A (2 of 2) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled protein_coding Danio_rerio
ENSG00000102468 HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled protein_coding Homo_sapiens

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