C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102468 HTR2A 9606 - 13:46831550-46897076 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000378688 HTR2A-001 46831550-46896038 protein_coding
  ENST00000542664 HTR2A-201 46831555-46897076 protein_coding
  ENST00000543956 HTR2A-202 46831555-46897076 protein_coding
  ENST00000612998 HTR2A-002 46895305-46895813 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378688ENST00000542664ENST00000543956ENST00000612998
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378688 0.005±0.00 0.059±0.00 0.025±0.00 0.889±0.00 N/A 0.194±0.06 0.011±0.00 0.180±0.00 N/A N/A 0.177±0.00 0.060±0.03 N/A 0.190±0.08
ENST00000542664 0.022±0.00 0.108±0.00 N/A 5.463±2.73 0.192±0.00 N/A 0.020±0.00 0.144±0.00 0.209±0.00 0.030±0.00 N/A 0.065±0.03 0.023±0.00 0.155±0.06
ENST00000543956 N/A N/A 0.009±0.00 N/A 0.011±0.00 N/A 0.024±0.00 N/A 0.007±0.00 0.049±0.00 N/A N/A 0.046±0.00 N/A
ENST00000612998 N/A N/A 0.678±0.00 N/A N/A N/A N/A N/A 0.880±0.00 0.339±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00021K CIL_00021K_0002 CGP 13:46771256-46897076

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001659 IEA temperature homeostasis
GO:0001965 IEA G-protein alpha-subunit binding
GO:0004930 IEA G-protein coupled receptor activity
GO:0004993 IDA serotonin receptor activity
GO:0005515 IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006874 IDA cellular calcium ion homeostasis
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007202 IDA activation of phospholipase C activity
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007208 IEA phospholipase C-activating serotonin receptor signaling pathway
GO:0007210 IMP serotonin receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007568 IEA aging
GO:0007613 IEA memory
GO:0008144 IDA drug binding
GO:0008219 IEA cell death
GO:0008284 IEA positive regulation of cell proliferation
GO:0010513 IDA positive regulation of phosphatidylinositol biosynthetic process
GO:0014059 IEA regulation of dopamine secretion
GO:0014065 IDA phosphatidylinositol 3-kinase signaling
GO:0014824 IEA artery smooth muscle contraction
GO:0014832 IEA urinary bladder smooth muscle contraction
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019233 IEA sensory perception of pain
GO:0030425 IEA dendrite
GO:0030431 IEA sleep
GO:0031410 IEA cytoplasmic vesicle
GO:0032403 IEA protein complex binding
GO:0033674 IEA positive regulation of kinase activity
GO:0042493 IDA response to drug
GO:0043025 IEA neuronal cell body
GO:0043198 IEA dendritic shaft
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0044380 IEA protein localization to cytoskeleton
GO:0045600 IEA positive regulation of fat cell differentiation
GO:0045821 IEA positive regulation of glycolytic process
GO:0045907 IEA positive regulation of vasoconstriction
GO:0046883 IEA regulation of hormone secretion
GO:0048148 IEA behavioral response to cocaine
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795 IEA regulation of behavior
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0051378 IDA serotonin binding
GO:0051967 IEA negative regulation of synaptic transmission, glutamatergic
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070852 IEA cell body fiber
GO:0071886 IDA 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057029 htr2a 5-hydroxytryptamine (serotonin) receptor 2A protein_coding Danio_rerio
ENSDARG00000058165 HTR2A (2 of 2) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled protein_coding Danio_rerio
ENSMUSG00000034997 Htr2a 5-hydroxytryptamine (serotonin) receptor 2A protein_coding Mus_musculus

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