C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000036867 Smad6 10090 - 9:63953076-64022059 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041029 Smad6-001 63953076-64022059 protein_coding
  ENSMUST00000144323 Smad6-002 63954009-64016987 processed_transcript
  ENSMUST00000179458 Smad6-003 64021760-64022032 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041029ENSMUST00000144323
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041029 6.051±0.65 14.340±3.45 10.512±2.19 1.331±0.57 6.253±3.31 17.920±1.69 4.407±1.00 7.111±1.43 3.628±0.79 109.068±16.85 1.534±0.39 10.717±4.76 3.269±1.52 2.606±0.37
ENSMUST00000144323 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.521±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008R9 CIL_0008R9_0002 VISTA 9:63580198-64181507
CIL_0008Q7 CIL_0008Q7_0002 VISTA 9:63744784-64346949

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001657 IEP ureteric bud development
GO:0003682 ISS chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005667 IEA transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006955 IEA immune response
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007352 IEA zygotic specification of dorsal/ventral axis
GO:0008285 IEA negative regulation of cell proliferation
GO:0010991 IEA negative regulation of SMAD protein complex assembly
GO:0030509 ISS BMP signaling pathway
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0030617 IEA transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031589 ISS cell-substrate adhesion
GO:0031625 IEA ubiquitin protein ligase binding
GO:0034616 IEA response to laminar fluid shear stress
GO:0034713 IEA type I transforming growth factor beta receptor binding
GO:0035556 IEA intracellular signal transduction
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 ISO protein complex
GO:0043627 IEA response to estrogen
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045444 ISS fat cell differentiation
GO:0045907 TAS positive regulation of vasoconstriction
GO:0045908 TAS negative regulation of vasodilation
GO:0046872 IEA metal ion binding
GO:0060394 IEA negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060948 TAS cardiac vascular smooth muscle cell development
GO:0060977 TAS coronary vasculature morphogenesis
GO:0070410 IEA co-SMAD binding
GO:0070411 IEA I-SMAD binding
GO:0070412 IEA R-SMAD binding
GO:0070698 IEA type I activin receptor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031763 smad6b SMAD family member 6b protein_coding Danio_rerio
ENSG00000137834 SMAD6 SMAD family member 6 protein_coding Homo_sapiens

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