C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitochondrial antiviral signaling protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037523 Mavs 10090 + 2:131234063-131248025 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041362 Mavs-001 131234067-131248025 protein_coding
  ENSMUST00000110199 Mavs-003 131234105-131248025 protein_coding
  ENSMUST00000130597 Mavs-002 131234063-131248022 nonsense_mediated_decay
  ENSMUST00000132694 Mavs-004 131241934-131245665 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041362ENSMUST00000110199ENSMUST00000130597
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041362 21.993±4.25 36.346±2.67 14.167±0.13 1.837±1.22 33.323±12.09 21.040±2.45 23.547±0.99 32.165±4.21 20.937±9.91 17.720±2.48 9.190±1.52 27.427±10.05 8.471±4.72 3.875±1.85
ENSMUST00000110199 10.060±2.11 9.568±1.05 4.817±1.51 0.339±0.15 12.469±1.07 16.750±3.48 4.714±1.05 18.801±3.12 19.396±10.29 6.127±0.86 6.697±1.82 11.331±3.32 3.478±1.52 1.353±0.78
ENSMUST00000130597 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.691±0.00 N/A N/A 1.081±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00034V CIL_00034V_0002 CGP 2:131207078-131248025
CIL_00067O CIL_00067O_0003 CGP 2:131234063-131299188

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002218 IEA activation of innate immune response
GO:0002230 ISS positive regulation of defense response to virus by host
GO:0004871 IMP signal transducer activity
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005741 TAS mitochondrial outer membrane
GO:0005777 IDA peroxisome
GO:0005778 IEA peroxisomal membrane
GO:0007165 IMP signal transduction
GO:0016021 IEA integral component of membrane
GO:0019901 IEA protein kinase binding
GO:0031966 IEA mitochondrial membrane
GO:0032481 IMP positive regulation of type I interferon production
GO:0032727 ISS positive regulation of interferon-alpha production
GO:0032728 ISS positive regulation of interferon-beta production
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0033160 IEA positive regulation of protein import into nucleus, translocation
GO:0039529 IGI RIG-I signaling pathway
GO:0042742 ISS defense response to bacterium
GO:0042993 IEA positive regulation of transcription factor import into nucleus
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 IMP negative regulation of viral genome replication
GO:0045087 ISS innate immune response
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050700 IEA CARD domain binding
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051607 IEA defense response to virus
GO:0060340 IEA positive regulation of type I interferon-mediated signaling pathway
GO:0071360 IEA cellular response to exogenous dsRNA
GO:0071651 IEA positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071660 IEA positive regulation of IP-10 production
GO:1900063 IMP regulation of peroxisome organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069733 mavs mitochondrial antiviral signaling protein protein_coding Danio_rerio
ENSG00000088888 MAVS mitochondrial antiviral signaling protein protein_coding Homo_sapiens

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