C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transducer of ErbB-2.1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037573 Tob1 10090 + 11:94211454-94215495 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041589 Tob1-001 94211454-94215495 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041589
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041589 27.828±2.04 300.776±57.59 19.304±1.45 9.881±2.05 97.650±59.59 172.819±13.49 18.561±4.06 45.952±16.93 37.311±29.44 47.710±16.44 56.292±12.59 116.055±39.12 7.068±3.70 32.128±12.67

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003714 IDA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0007184 IDA SMAD protein import into nucleus
GO:0008285 ISS negative regulation of cell proliferation
GO:0017148 ISS negative regulation of translation
GO:0030014 ISS CCR4-NOT complex
GO:0030514 IDA negative regulation of BMP signaling pathway
GO:0030971 ISS receptor tyrosine kinase binding
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0046332 IDA SMAD binding
GO:0060212 ISS negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060213 ISS positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153 ISS positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2001141 IDA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021372 tob1b transducer of ERBB2, 1b protein_coding Danio_rerio
ENSDARG00000032619 tob1a transducer of ERBB2, 1a protein_coding Danio_rerio
ENSG00000141232 TOB1 transducer of ERBB2, 1 protein_coding Homo_sapiens

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