C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transducer of ERBB2, 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141232 TOB1 9606 - 17:50862223-50867978 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268957 TOB1-002 50862980-50867978 protein_coding
  ENST00000499247 TOB1-001 50862223-50866345 protein_coding
  ENST00000509385 TOB1-003 50863369-50866354 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000268957ENST00000499247ENST00000509385
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000268957 N/A N/A 3.349±0.00 1.812±0.00 2.602±0.00 2.899±0.00 N/A N/A 3.483±0.00 N/A 18.814±0.00 13.477±7.06 2.714±1.39 12.119±0.00
ENST00000499247 4.490±0.00 N/A N/A 7.767±0.00 4.509±1.58 6.158±0.58 4.854±4.40 18.551±0.00 5.850±3.30 3.362±2.06 16.219±10.49 7.615±6.92 1.606±0.69 9.838±7.67
ENST00000509385 10.988±0.00 6.847±0.00 N/A 15.451±0.00 21.562±0.00 7.420±0.00 11.733±0.00 23.090±0.00 8.198±3.33 4.173±0.00 22.503±2.87 29.931±2.16 4.384±0.00 18.780±4.32

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007KM CIL_0007KM_0001 UCNEbase 17:50750455-50862724
CIL_0004X3 CIL_0004X3_0003 CGP 17:50834650-50867978
CIL_0004X0 CIL_0004X0_0003 CGP 17:50862223-51120865

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003714 IEA transcription corepressor activity
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0007184 IEA SMAD protein import into nucleus
GO:0008285 IDA negative regulation of cell proliferation
GO:0009967 TAS positive regulation of signal transduction
GO:0017148 IDA negative regulation of translation
GO:0030014 IDA CCR4-NOT complex
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0030971 IDA receptor tyrosine kinase binding
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0046332 IEA SMAD binding
GO:0060212 IDA negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060213 IDA positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153 IDA positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2001141 IEA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021372 tob1b transducer of ERBB2, 1b protein_coding Danio_rerio
ENSDARG00000032619 tob1a transducer of ERBB2, 1a protein_coding Danio_rerio
ENSMUSG00000037573 Tob1 transducer of ErbB-2.1 protein_coding Mus_musculus

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