C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: forkhead box P3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039521 Foxp3 10090 + X:7579676-7595243 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000045566 Foxp3-201 7586273-7595243 protein_coding
  ENSMUST00000115738 Foxp3-003 7580483-7595234 protein_coding
  ENSMUST00000115739 Foxp3-002 7579693-7595234 protein_coding
  ENSMUST00000115740 Foxp3-001 7579676-7595243 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastENSMUST00000045566ENSMUST00000115739
Transcript ID Breast
ENSMUST00000045566 0.984±0.00
ENSMUST00000115739 2.311±0.78

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001782 IMP B cell homeostasis
GO:0001816 IMP cytokine production
GO:0002262 IMP myeloid cell homeostasis
GO:0002361 IMP CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002456 IMP T cell mediated immunity
GO:0002507 IDA tolerance induction
GO:0002513 IMP tolerance induction to self antigen
GO:0002637 IMP regulation of immunoglobulin production
GO:0002666 IMP positive regulation of T cell tolerance induction
GO:0002669 IMP positive regulation of T cell anergy
GO:0002677 IMP negative regulation of chronic inflammatory response
GO:0002725 ISS negative regulation of T cell cytokine production
GO:0002851 IMP positive regulation of peripheral T cell tolerance induction
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 IDA transcription corepressor activity
GO:0005515 IEA protein binding
GO:0005622 IDA intracellular
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0008285 ISS negative regulation of cell proliferation
GO:0009615 IEA response to virus
GO:0010628 IDA positive regulation of gene expression
GO:0031064 IEA negative regulation of histone deacetylation
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032689 ISS negative regulation of interferon-gamma production
GO:0032693 ISS negative regulation of interleukin-10 production
GO:0032703 ISS negative regulation of interleukin-2 production
GO:0032713 ISS negative regulation of interleukin-4 production
GO:0032714 IMP negative regulation of interleukin-5 production
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0032753 IMP positive regulation of interleukin-4 production
GO:0032792 ISS negative regulation of CREB transcription factor activity
GO:0032831 IMP positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 IDA positive regulation of transforming growth factor beta1 production
GO:0033092 IMP positive regulation of immature T cell proliferation in thymus
GO:0035035 IEA histone acetyltransferase binding
GO:0035066 IDA positive regulation of histone acetylation
GO:0035067 IDA negative regulation of histone acetylation
GO:0042036 ISS negative regulation of cytokine biosynthetic process
GO:0042110 ISS T cell activation
GO:0042130 ISS negative regulation of T cell proliferation
GO:0042803 ISS protein homodimerization activity
GO:0042826 IEA histone deacetylase binding
GO:0043433 ISS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 ISS sequence-specific DNA binding
GO:0045066 IDA regulatory T cell differentiation
GO:0045077 IDA negative regulation of interferon-gamma biosynthetic process
GO:0045085 ISS negative regulation of interleukin-2 biosynthetic process
GO:0045591 IDA positive regulation of regulatory T cell differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048294 IMP negative regulation of isotype switching to IgE isotypes
GO:0048302 IMP regulation of isotype switching to IgG isotypes
GO:0050672 IMP negative regulation of lymphocyte proliferation
GO:0050710 ISS negative regulation of cytokine secretion
GO:0050728 IMP negative regulation of inflammatory response
GO:0050777 ISS negative regulation of immune response
GO:0050852 IMP T cell receptor signaling pathway
GO:0051525 ISS NFAT protein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055750 foxp3a forkhead box P3a protein_coding Danio_rerio
ENSDARG00000078279 foxp3b forkhead box P3b protein_coding Danio_rerio
ENSG00000049768 FOXP3 forkhead box P3 protein_coding Homo_sapiens

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