C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: forkhead box P3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000049768 FOXP3 9606 - X:49250436-49264826 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000376197 FOXP3-002 49251334-49259240 protein_coding
  ENST00000376199 FOXP3-201 49250439-49264826 protein_coding
  ENST00000376207 FOXP3-001 49250436-49264826 protein_coding
  ENST00000455775 FOXP3-202 49250439-49264826 protein_coding
  ENST00000518685 FOXP3-003 49251334-49258527 protein_coding
  ENST00000557224 FOXP3-004 49251334-49258505 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001782 IEA B cell homeostasis
GO:0001816 IEA cytokine production
GO:0002262 IEA myeloid cell homeostasis
GO:0002361 IEA CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002456 IEA T cell mediated immunity
GO:0002507 IEA tolerance induction
GO:0002513 IEA tolerance induction to self antigen
GO:0002637 IEA regulation of immunoglobulin production
GO:0002666 IEA positive regulation of T cell tolerance induction
GO:0002669 IEA positive regulation of T cell anergy
GO:0002677 IEA negative regulation of chronic inflammatory response
GO:0002725 IDA negative regulation of T cell cytokine production
GO:0002851 IEA positive regulation of peripheral T cell tolerance induction
GO:0003700 NAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 IEA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 NAS cytoplasm
GO:0006338 NAS chromatin remodeling
GO:0006355 NAS:IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008285 IDA negative regulation of cell proliferation
GO:0009615 IEP response to virus
GO:0010628 IEA positive regulation of gene expression
GO:0031064 IGI negative regulation of histone deacetylation
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032689 IDA negative regulation of interferon-gamma production
GO:0032693 IDA negative regulation of interleukin-10 production
GO:0032703 IDA negative regulation of interleukin-2 production
GO:0032713 IDA negative regulation of interleukin-4 production
GO:0032714 IEA negative regulation of interleukin-5 production
GO:0032715 IEA negative regulation of interleukin-6 production
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032753 IEA positive regulation of interleukin-4 production
GO:0032792 IDA negative regulation of CREB transcription factor activity
GO:0032831 IEA positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 IEA positive regulation of transforming growth factor beta1 production
GO:0033092 IEA positive regulation of immature T cell proliferation in thymus
GO:0035035 IPI histone acetyltransferase binding
GO:0035066 IMP positive regulation of histone acetylation
GO:0035067 IEA negative regulation of histone acetylation
GO:0042036 IDA negative regulation of cytokine biosynthetic process
GO:0042110 IDA T cell activation
GO:0042130 IDA negative regulation of T cell proliferation
GO:0042803 IPI protein homodimerization activity
GO:0042826 IPI histone deacetylase binding
GO:0043029 NAS T cell homeostasis
GO:0043234 NAS protein complex
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA:IEA sequence-specific DNA binding
GO:0045066 IEA regulatory T cell differentiation
GO:0045077 IEA negative regulation of interferon-gamma biosynthetic process
GO:0045085 IMP negative regulation of interleukin-2 biosynthetic process
GO:0045591 IEA positive regulation of regulatory T cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046007 NAS negative regulation of activated T cell proliferation
GO:0046872 IEA metal ion binding
GO:0048294 IEA negative regulation of isotype switching to IgE isotypes
GO:0048302 IEA regulation of isotype switching to IgG isotypes
GO:0050672 IEA negative regulation of lymphocyte proliferation
GO:0050710 IDA negative regulation of cytokine secretion
GO:0050728 IEA negative regulation of inflammatory response
GO:0050777 IDA negative regulation of immune response
GO:0050852 IEA T cell receptor signaling pathway
GO:0051059 NAS NF-kappaB binding
GO:0051525 IPI NFAT protein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055750 foxp3a forkhead box P3a protein_coding Danio_rerio
ENSDARG00000078279 foxp3b forkhead box P3b protein_coding Danio_rerio
ENSMUSG00000039521 Foxp3 forkhead box P3 protein_coding Mus_musculus

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