C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: toll-like receptor 9
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000045322 Tlr9 10090 + 9:106222598-106226883 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000062241 Tlr9-001 106222598-106226883 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000062241
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000062241 1.363±0.71 1.110±0.14 0.929±0.39 0.165±0.08 8.503±3.71 1.567±0.27 0.394±0.12 0.973±0.36 0.207±0.08 2.122±0.66 0.095±0.17 2.010±0.95 0.099±0.03 0.355±0.25

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NT CIL_0008NT_0002 VISTA 9:106082995-106685663
CIL_00087C CIL_00087C_0002 VISTA 9:106116951-106718793

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001774 IEA microglial cell activation
GO:0002224 IEA toll-like receptor signaling pathway
GO:0002237 TAS response to molecule of bacterial origin
GO:0002755 IEA MyD88-dependent toll-like receptor signaling pathway
GO:0004888 IEA transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0005764 IDA lysosome
GO:0005768 IDA endosome
GO:0005783 IDA endoplasmic reticulum
GO:0005886 ISS plasma membrane
GO:0006954 IEA inflammatory response
GO:0006955 IMP immune response
GO:0008584 IEA male gonad development
GO:0009615 IMP response to virus
GO:0010508 IEA positive regulation of autophagy
GO:0016021 IEA integral component of membrane
GO:0030277 IMP maintenance of gastrointestinal epithelium
GO:0032009 IDA early phagosome
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032728 IDA positive regulation of interferon-beta production
GO:0032733 IDA positive regulation of interleukin-10 production
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0032741 IDA positive regulation of interleukin-18 production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0034162 IEA toll-like receptor 9 signaling pathway
GO:0035197 ISS siRNA binding
GO:0045078 ISS positive regulation of interferon-gamma biosynthetic process
GO:0045087 TAS innate immune response
GO:0045322 IEA unmethylated CpG binding
GO:0045356 ISS positive regulation of interferon-alpha biosynthetic process
GO:0045359 ISS positive regulation of interferon-beta biosynthetic process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050707 IEA regulation of cytokine secretion
GO:0050727 IMP regulation of inflammatory response
GO:0050729 IEA positive regulation of inflammatory response
GO:0050864 IGI regulation of B cell activation
GO:0051607 IGI defense response to virus
GO:0051770 IDA positive regulation of nitric-oxide synthase biosynthetic process
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071248 IEA cellular response to metal ion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044490 tlr9 toll-like receptor 9 protein_coding Danio_rerio
ENSG00000173366 TLR9 TLR9 {ECO:0000313|EMBL:ACQ41818.1} protein_coding Homo_sapiens
ENSG00000239732 TLR9 toll-like receptor 9 protein_coding Homo_sapiens

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