C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin receptor substrate 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000055980 Irs1 10090 - 1:82233101-82291416 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000069799 Irs1-001 82233101-82291416 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000069799
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000069799 14.065±4.14 4.078±0.95 1.519±0.14 1.329±0.42 12.140±6.08 2.425±0.33 3.010±0.30 1.917±0.88 1.125±0.91 5.691±0.61 2.883±0.63 16.006±7.29 0.258±0.14 0.160±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004AN CIL_0004AN_0003 CGP 1:81076950-82291416

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002053 IGI positive regulation of mesenchymal cell proliferation
GO:0005159 IEA insulin-like growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005901 IEA caveola
GO:0008286 IEA insulin receptor signaling pathway
GO:0010468 IMP regulation of gene expression
GO:0010907 IEA positive regulation of glucose metabolic process
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0016042 IMP lipid catabolic process
GO:0019901 IDA protein kinase binding
GO:0030335 IGI positive regulation of cell migration
GO:0030879 IGI mammary gland development
GO:0032000 IEA positive regulation of fatty acid beta-oxidation
GO:0032868 IEA response to insulin
GO:0032869 IDA cellular response to insulin stimulus
GO:0034504 IDA protein localization to nucleus
GO:0036064 IDA ciliary basal body
GO:0043491 IGI protein kinase B signaling
GO:0043548 IDA phosphatidylinositol 3-kinase binding
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045725 IEA positive regulation of glycogen biosynthetic process
GO:0046326 IEA positive regulation of glucose import
GO:0046676 IEA negative regulation of insulin secretion
GO:0048009 IEA insulin-like growth factor receptor signaling pathway
GO:2001275 IEA positive regulation of glucose import in response to insulin stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054087 irs1 insulin receptor substrate 1 protein_coding Danio_rerio
ENSG00000169047 IRS1 insulin receptor substrate 1 protein_coding Homo_sapiens

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