C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin receptor substrate 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169047 IRS1 9606 - 2:226731317-226799759 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000305123 IRS1-001 226731317-226799759 protein_coding
  ENST00000498335 IRS1-002 226792138-226795246 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000305123
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000305123 1.518±0.00 0.952±0.00 1.163±0.00 0.843±0.24 3.861±0.91 2.105±1.03 1.471±0.95 2.411±0.43 2.310±0.92 1.793±0.98 2.242±1.21 4.879±3.36 3.857±0.81 0.853±0.56

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004AN CIL_0004AN_0002 CGP 2:225400648-226799759
CIL_0004AO CIL_0004AO_0002 CGP 2:226731317-226999215

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0004871 IEA signal transducer activity
GO:0005068 ISS transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 ISS protein kinase C binding
GO:0005158 IPI:IEA insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005899 ISS insulin receptor complex
GO:0005901 IDA caveola
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008284 NAS positive regulation of cell proliferation
GO:0008286 IDA insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010468 IEA regulation of gene expression
GO:0010907 IMP positive regulation of glucose metabolic process
GO:0014065 IDA phosphatidylinositol 3-kinase signaling
GO:0016042 IEA lipid catabolic process
GO:0019901 IEA protein kinase binding
GO:0030335 IEA positive regulation of cell migration
GO:0030879 IEA mammary gland development
GO:0032000 IMP positive regulation of fatty acid beta-oxidation
GO:0032868 IDA response to insulin
GO:0032869 IMP cellular response to insulin stimulus
GO:0034504 IEA protein localization to nucleus
GO:0036064 IEA ciliary basal body
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042169 ISS SH2 domain binding
GO:0042593 TAS glucose homeostasis
GO:0043231 ISS intracellular membrane-bounded organelle
GO:0043434 ISS response to peptide hormone
GO:0043491 IEA protein kinase B signaling
GO:0043548 ISS phosphatidylinositol 3-kinase binding
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 TAS innate immune response
GO:0045725 IMP positive regulation of glycogen biosynthetic process
GO:0046326 IMP positive regulation of glucose import
GO:0046627 ISS negative regulation of insulin receptor signaling pathway
GO:0046628 ISS positive regulation of insulin receptor signaling pathway
GO:0046676 IDA negative regulation of insulin secretion
GO:0048009 IPI insulin-like growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:2001275 IDA positive regulation of glucose import in response to insulin stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054087 irs1 insulin receptor substrate 1 protein_coding Danio_rerio
ENSMUSG00000055980 Irs1 insulin receptor substrate 1 protein_coding Mus_musculus

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