C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glucokinase regulatory protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000059434 Gckr 10090 + 5:31297581-31327300 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000072228 Gckr-201 31297581-31327300 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000072228
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000072228 0.042±0.01 0.055±0.02 0.022±0.00 0.187±0.00 0.109±0.07 0.091±0.00 0.048±0.02 19.580±15.04 0.029±0.01 0.166±0.04 0.724±0.76 0.142±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001DA CIL_0001DA_0002 CGP 5:31292255-31327300

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IMP protein import into nucleus, translocation
GO:0001678 IMP cellular glucose homeostasis
GO:0004857 IEA enzyme inhibitor activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 ISS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 IEA cytosol
GO:0005975 IEA carbohydrate metabolic process
GO:0009750 IEA response to fructose
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030246 IEA carbohydrate binding
GO:0033132 ISS negative regulation of glucokinase activity
GO:0033133 IMP positive regulation of glucokinase activity
GO:0034504 IMP protein localization to nucleus
GO:0043086 IEA negative regulation of catalytic activity
GO:0046415 IEA urate metabolic process
GO:0070095 ISS fructose-6-phosphate binding
GO:0070328 IEA triglyceride homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000086620 gckr glucokinase (hexokinase 4) regulator protein_coding Danio_rerio
ENSG00000084734 GCKR glucokinase (hexokinase 4) regulator protein_coding Homo_sapiens

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