C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glucokinase (hexokinase 4) regulator
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000084734 GCKR 9606 + 2:27496842-27523684 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264717 GCKR-001 27496842-27523684 protein_coding
  ENST00000411584 GCKR-006 27506510-27509791 protein_coding
  ENST00000417872 GCKR-003 27496848-27501163 nonsense_mediated_decay
  ENST00000453813 GCKR-004 27497268-27501830 protein_coding
  ENST00000472290 GCKR-002 27496883-27506891 retained_intron
  ENST00000478147 GCKR-005 27507341-27508211 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264717ENST00000411584ENST00000417872ENST00000453813ENST00000472290ENST00000478147
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264717 N/A N/A 0.092±0.00 N/A N/A N/A 9.149±0.00 28.704±0.00 N/A N/A 0.710±0.59 0.017±0.00 0.494±0.30
ENST00000411584 0.235±0.00 0.120±0.00 N/A 0.057±0.02 N/A 0.086±0.00 N/A N/A 0.147±0.00 0.016±0.00 N/A N/A N/A
ENST00000417872 N/A 0.114±0.00 N/A 0.037±0.00 N/A N/A 0.143±0.00 0.438±0.00 N/A N/A 0.275±0.00 N/A N/A
ENST00000453813 N/A 0.145±0.00 N/A 0.075±0.00 0.129±0.00 N/A N/A N/A N/A N/A 0.354±0.27 N/A N/A
ENST00000472290 N/A N/A N/A N/A N/A 0.013±0.00 N/A N/A N/A 0.085±0.00 0.204±0.17 0.040±0.00 0.708±0.54
ENST00000478147 N/A N/A N/A 0.127±0.00 N/A N/A 0.119±0.00 1.950±0.00 N/A N/A 0.063±0.00 N/A 0.449±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001DA CIL_0001DA_0001 CGP 2:27491883-27523684

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 ISS protein import into nucleus, translocation
GO:0001678 IEA cellular glucose homeostasis
GO:0004857 IEA enzyme inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005654 ISS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005975 TAS carbohydrate metabolic process
GO:0008645 TAS hexose transport
GO:0009750 IDA response to fructose
GO:0010827 TAS regulation of glucose transport
GO:0015758 TAS glucose transport
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030246 IEA carbohydrate binding
GO:0033132 IDA negative regulation of glucokinase activity
GO:0033133 IEA positive regulation of glucokinase activity
GO:0034504 IEA protein localization to nucleus
GO:0043086 IEA negative regulation of catalytic activity
GO:0044281 TAS small molecule metabolic process
GO:0046415 IMP urate metabolic process
GO:0055085 TAS transmembrane transport
GO:0070095 IDA fructose-6-phosphate binding
GO:0070328 IMP triglyceride homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000086620 gckr glucokinase (hexokinase 4) regulator protein_coding Danio_rerio
ENSMUSG00000059434 Gckr glucokinase regulatory protein protein_coding Mus_musculus

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