C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin beta 1 binding protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000062352 Itgb1bp1 10090 - 12:21240825-21286237 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000076260 Itgb1bp1-001 21269806-21286237 protein_coding
  ENSMUST00000172834 Itgb1bp1-006 21271288-21286185 protein_coding
  ENSMUST00000172962 Itgb1bp1-003 21240825-21247323 processed_transcript
  ENSMUST00000173614 Itgb1bp1-007 21271426-21272770 retained_intron
  ENSMUST00000173688 Itgb1bp1-005 21270704-21272123 protein_coding
  ENSMUST00000173729 Itgb1bp1-004 21270093-21286097 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000076260ENSMUST00000172834ENSMUST00000173729
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000076260 13.050±3.48 15.374±2.73 8.689±0.00 7.876±0.03 6.824±0.54 4.685±0.75 7.074±1.75 4.311±0.88 11.246±1.14 1.835±0.36 6.315±0.91 4.368±1.43 32.914±5.27
ENSMUST00000172834 N/A N/A N/A N/A N/A N/A N/A 7.285±1.39 N/A 9.354±2.18 19.064±0.86 9.717±3.55 28.772±9.04
ENSMUST00000173729 14.669±5.40 10.219±1.67 N/A N/A 6.507±1.98 3.945±0.57 4.594±0.45 N/A N/A 2.839±0.55 6.372±1.18 2.303±0.02 30.421±7.60

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007AV CIL_0007AV_0003 CGP 12:21111748-21286237
CIL_00057K CIL_00057K_0002 CGP 12:21240825-21315056

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0002043 ISS blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0005092 ISS GDP-dissociation inhibitor activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 ISS cytosol
GO:0005856 IDA cytoskeleton
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006933 IDA negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007160 ISS cell-matrix adhesion
GO:0007219 IEA Notch signaling pathway
GO:0007229 ISS integrin-mediated signaling pathway
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008565 ISS protein transporter activity
GO:0010595 ISS positive regulation of endothelial cell migration
GO:0010764 IDA negative regulation of fibroblast migration
GO:0015031 ISS protein transport
GO:0019900 IPI kinase binding
GO:0019901 IDA protein kinase binding
GO:0030027 ISS lamellipodium
GO:0030154 IEA cell differentiation
GO:0031214 IEA biomineral tissue development
GO:0032091 ISS negative regulation of protein binding
GO:0032148 ISS activation of protein kinase B activity
GO:0032403 ISS protein complex binding
GO:0033622 IDA integrin activation
GO:0033628 IMP regulation of cell adhesion mediated by integrin
GO:0035148 ISS tube formation
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043113 IDA receptor clustering
GO:0044344 ISS cellular response to fibroblast growth factor stimulus
GO:0045747 ISS positive regulation of Notch signaling pathway
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048471 ISS perinuclear region of cytoplasm
GO:0050880 ISS regulation of blood vessel size
GO:0051451 IMP myoblast migration
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0051781 IEA positive regulation of cell division
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0051895 IMP negative regulation of focal adhesion assembly
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0070062 IEA extracellular vesicular exosome
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0071944 ISS cell periphery
GO:0090051 ISS negative regulation of cell migration involved in sprouting angiogenesis
GO:0090314 IDA positive regulation of protein targeting to membrane
GO:0090315 ISS negative regulation of protein targeting to membrane
GO:1900025 ISS negative regulation of substrate adhesion-dependent cell spreading
GO:2001044 IDA regulation of integrin-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007169 itgb1bp1 integrin beta 1 binding protein 1 protein_coding Danio_rerio
ENSG00000119185 ITGB1BP1 integrin beta 1 binding protein 1 protein_coding Homo_sapiens

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