C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CDC-like kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000068917 Clk2 10090 + 3:89164795-89176921 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000090927 Clk2-002 89164818-89176921 protein_coding
  ENSMUST00000121212 Clk2-001 89164795-89176921 protein_coding
  ENSMUST00000121931 Clk2-003 89164840-89176921 protein_coding
  ENSMUST00000128318 Clk2-005 89164979-89176921 nonsense_mediated_decay
  ENSMUST00000132830 Clk2-010 89173955-89175747 retained_intron
  ENSMUST00000133323 Clk2-009 89167164-89170409 retained_intron
  ENSMUST00000138822 Clk2-004 89164819-89176919 retained_intron
  ENSMUST00000139221 Clk2-011 89175035-89175971 processed_transcript
  ENSMUST00000148265 Clk2-008 89164819-89173457 protein_coding
  ENSMUST00000152205 Clk2-007 89164817-89167204 protein_coding
  ENSMUST00000153255 Clk2-006 89172165-89176080 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000090927ENSMUST00000121212ENSMUST00000121931ENSMUST00000128318ENSMUST00000133323ENSMUST00000138822ENSMUST00000148265ENSMUST00000153255
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000090927 5.604±2.00 5.344±0.41 7.642±0.34 6.752±1.64 3.588±0.00 3.263±0.71 2.565±0.00 2.638±0.44 3.168±1.25 5.326±0.88 1.409±0.52 8.087±1.64 4.702±1.74 5.842±0.97
ENSMUST00000121212 N/A 4.903±0.00 N/A N/A N/A 3.202±0.00 2.034±0.00 N/A N/A N/A 3.362±1.06 9.174±0.00 N/A N/A
ENSMUST00000121931 4.138±0.87 6.258±1.06 12.009±0.23 16.654±1.93 6.256±0.72 5.057±2.01 2.892±0.98 3.525±0.94 7.432±3.93 6.770±1.11 3.308±0.49 8.569±1.48 5.942±1.60 9.634±0.95
ENSMUST00000128318 11.847±4.01 13.242±5.58 7.693±0.00 7.529±1.13 10.962±2.75 7.910±2.54 3.572±1.27 7.975±0.88 4.212±1.66 8.605±0.98 N/A 15.866±3.10 11.810±5.85 N/A
ENSMUST00000133323 12.609±0.00 N/A N/A N/A 11.353±1.15 N/A 3.656±0.02 N/A N/A N/A N/A 15.338±0.74 N/A N/A
ENSMUST00000138822 6.987±2.52 12.296±0.93 8.996±0.91 12.236±1.75 8.524±1.39 7.499±2.31 1.968±0.61 3.622±0.68 4.515±1.84 7.865±0.53 1.205±0.38 14.018±3.84 4.725±0.18 4.200±0.52
ENSMUST00000148265 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 40.141±0.00 N/A 27.911±0.00
ENSMUST00000153255 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.711±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004712 IEA protein serine/threonine/tyrosine kinase activity
GO:0004713 IDA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0006468 IDA protein phosphorylation
GO:0010033 IDA response to organic substance
GO:0010212 ISS response to ionizing radiation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0032526 IDA response to retinoic acid
GO:0043484 ISS regulation of RNA splicing
GO:0045721 IMP negative regulation of gluconeogenesis
GO:0046777 IDA protein autophosphorylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059870 clk2b CDC-like kinase 2b protein_coding Danio_rerio
ENSDARG00000062954 clk2a CDC-like kinase 2a protein_coding Danio_rerio
ENSG00000176444 CLK2 CDC-like kinase 2 protein_coding Homo_sapiens

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