C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: endoglin
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000009705 Eng-001 ENSMUSG00000026814 10090 + 2:32646595-32682658 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaENSMUST00000009705
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta
ENSMUST00000009705 52.145±11.73 101.875±8.49 17.488±0.73 6.464±0.53 53.428±24.87 25.144±1.15 45.265±16.07 69.018±7.95 17.035±6.65 267.381±48.52 40.245±17.18 7.395±4.70

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YA CIL_0008YA_0002 VISTA 2:32608279-33209524

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001300 IEP chronological cell aging
GO:0001525 IMP angiogenesis
GO:0001569 IMP patterning of blood vessels
GO:0001570 IMP vasculogenesis
GO:0001666 IEA response to hypoxia
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001937 IEA negative regulation of endothelial cell proliferation
GO:0001947 IMP heart looping
GO:0003084 IEA positive regulation of systemic arterial blood pressure
GO:0003273 IMP cell migration involved in endocardial cushion formation
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005072 IEA transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005114 IEA type II transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005534 IEA galactose binding
GO:0005539 IEA glycosaminoglycan binding
GO:0005615 IEA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005925 IEA focal adhesion
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007155 IEA cell adhesion
GO:0007179 IC transforming growth factor beta receptor signaling pathway
GO:0007507 IMP heart development
GO:0009897 IEA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010628 IEA positive regulation of gene expression
GO:0010862 IEA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016021 IEA integral component of membrane
GO:0016477 IEA cell migration
GO:0017015 TAS regulation of transforming growth factor beta receptor signaling pathway
GO:0022009 IEA central nervous system vasculogenesis
GO:0022617 IEA extracellular matrix disassembly
GO:0030336 IEA negative regulation of cell migration
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0031953 IEA negative regulation of protein autophosphorylation
GO:0031960 IEA response to corticosteroid
GO:0032967 IEA positive regulation of collagen biosynthetic process
GO:0034713 IEA type I transforming growth factor beta receptor binding
GO:0035556 IEA intracellular signal transduction
GO:0036273 IEA response to statin
GO:0042060 IEA wound healing
GO:0042803 IPI protein homodimerization activity
GO:0045766 TAS positive regulation of angiogenesis
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048745 IMP smooth muscle tissue development
GO:0048844 IMP artery morphogenesis
GO:0048845 IMP venous blood vessel morphogenesis
GO:0048870 IEA cell motility
GO:0050431 IDA transforming growth factor beta binding
GO:0051001 IEA negative regulation of nitric-oxide synthase activity
GO:0060326 IEA cell chemotaxis
GO:0060348 IEA bone development
GO:0060394 IEA negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070278 IEA extracellular matrix constituent secretion
GO:0070483 IEA detection of hypoxia
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071559 IEA response to transforming growth factor beta
GO:0072563 IDA endothelial microparticle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000344849 ENG-001 protein_coding Homo_sapiens 0 202
ENST00000373203 ENG-002 protein_coding Homo_sapiens 0 1544
ENST00000480266 ENG-201 protein_coding Homo_sapiens 0 1327

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