C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: chemokine (C-C motif) ligand 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000035938 Ccl5-001 ENSMUSG00000035042 10090 - 11:83525778-83530518 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000035938
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000035938 17.113±2.62 10.854±1.95 6.923±0.72 0.114±0.07 472.968±257.21 18.230±5.82 4.762±4.09 18.107±12.93 3.192±2.31 70.487±37.50 1.309±2.24 10.945±6.23 0.783±0.58 0.936±0.66

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003GO CIL_0003GO_0002 CGP 11:83511736-83530518

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0002230 IC positive regulation of defense response to virus by host
GO:0004435 IEA phosphatidylinositol phospholipase C activity
GO:0004672 IEA protein kinase activity
GO:0005515 IEA protein binding
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0006816 IEA calcium ion transport
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006887 IEA exocytosis
GO:0006954 IMP inflammatory response
GO:0006955 IEA immune response
GO:0007159 ISS leukocyte cell-cell adhesion
GO:0007186 ISS G-protein coupled receptor signaling pathway
GO:0007267 ISS cell-cell signaling
GO:0008009 ISS chemokine activity
GO:0009636 IEA response to toxic substance
GO:0010759 ISS positive regulation of macrophage chemotaxis
GO:0010820 ISS positive regulation of T cell chemotaxis
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 ISS positive regulation of smooth muscle cell migration
GO:0016004 IEA phospholipase activator activity
GO:0030298 ISS receptor signaling protein tyrosine kinase activator activity
GO:0030335 IEA positive regulation of cell migration
GO:0031328 ISS positive regulation of cellular biosynthetic process
GO:0031584 ISS activation of phospholipase D activity
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0031726 IDA CCR1 chemokine receptor binding
GO:0031730 ISS CCR5 chemokine receptor binding
GO:0033634 ISS positive regulation of cell-cell adhesion mediated by integrin
GO:0034097 IDA response to cytokine
GO:0034112 ISS positive regulation of homotypic cell-cell adhesion
GO:0034612 IDA response to tumor necrosis factor
GO:0042056 IEA chemoattractant activity
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042119 ISS neutrophil activation
GO:0042327 ISS positive regulation of phosphorylation
GO:0042379 IEA chemokine receptor binding
GO:0042531 ISS positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 ISS protein homodimerization activity
GO:0043491 IEA protein kinase B signaling
GO:0043621 ISS protein self-association
GO:0043623 ISS cellular protein complex assembly
GO:0043922 IEA negative regulation by host of viral transcription
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0045071 ISS negative regulation of viral genome replication
GO:0045744 IEA negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045785 ISS positive regulation of cell adhesion
GO:0046817 ISS chemokine receptor antagonist activity
GO:0048245 ISS eosinophil chemotaxis
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050796 ISS regulation of insulin secretion
GO:0050863 ISS regulation of T cell activation
GO:0050918 IEA positive chemotaxis
GO:0051262 ISS protein tetramerization
GO:0051928 IEA positive regulation of calcium ion transport
GO:0061098 ISS positive regulation of protein tyrosine kinase activity
GO:0070098 ISS chemokine-mediated signaling pathway
GO:0070100 ISS negative regulation of chemokine-mediated signaling pathway
GO:0070233 ISS negative regulation of T cell apoptotic process
GO:0070234 ISS positive regulation of T cell apoptotic process
GO:0071346 IEA cellular response to interferon-gamma
GO:0071347 IEA cellular response to interleukin-1
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071407 IEA cellular response to organic cyclic compound
GO:0090026 IDA positive regulation of monocyte chemotaxis
GO:1901214 ISS regulation of neuron death
GO:2000110 IMP negative regulation of macrophage apoptotic process
GO:2000343 NAS positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000406 ISO positive regulation of T cell migration
GO:2000503 IEA positive regulation of natural killer cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000603197 CCL5-001 protein_coding Homo_sapiens 0 346
ENST00000605140 CCL5-002 protein_coding Homo_sapiens 0 316
ENST00000605509 CCL5-003 protein_coding Homo_sapiens 4e-30 135
ENST00000613606 CCL5-201 protein_coding Homo_sapiens 0 346
ENST00000618639 CCL5-202 protein_coding Homo_sapiens 8e-30 135

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